4-phenylbutyric acid has been researched along with Renal Insufficiency, Chronic in 4 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Renal Insufficiency, Chronic: Conditions in which the KIDNEYS perform below the normal level for more than three months. Chronic kidney insufficiency is classified by five stages according to the decline in GLOMERULAR FILTRATION RATE and the degree of kidney damage (as measured by the level of PROTEINURIA). The most severe form is the end-stage renal disease (CHRONIC KIDNEY FAILURE). (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Proteinuria is one of the primary risk factors for the progression of chronic kidney disease (CKD) and has been implicated in the induction of endoplasmic reticulum (ER) stress." | 1.46 | Endoplasmic reticulum stress inhibition limits the progression of chronic kidney disease in the Dahl salt-sensitive rat. ( Ask, K; Brimble, E; Carlisle, RE; Chahal, J; Dickhout, JG; Lu, C; Upagupta, C; Yum, V, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Guo, J | 1 |
| Zhu, J | 1 |
| Ma, L | 1 |
| Shi, H | 1 |
| Hu, J | 1 |
| Zhang, S | 1 |
| Hou, L | 1 |
| Xu, F | 1 |
| An, Y | 1 |
| Yu, H | 1 |
| Ge, J | 1 |
| Zhu, Y | 1 |
| Chen, YL | 1 |
| Li, C | 1 |
| Ding, XY | 1 |
| Xu, GY | 1 |
| Hu, LL | 1 |
| Hou, FF | 1 |
| Zhou, QG | 1 |
| Yum, V | 1 |
| Carlisle, RE | 2 |
| Lu, C | 2 |
| Brimble, E | 1 |
| Chahal, J | 1 |
| Upagupta, C | 1 |
| Ask, K | 2 |
| Dickhout, JG | 2 |
| Mohammed-Ali, Z | 1 |
| Marway, MK | 1 |
| Lukic, D | 1 |
| Krepinsky, JC | 1 |
4 other studies available for 4-phenylbutyric acid and Renal Insufficiency, Chronic
| Article | Year |
|---|---|
Chronic Kidney Disease Exacerbates Myocardial Ischemia Reperfusion Injury: Role of Endoplasmic Reticulum Stress-Mediated Apoptosis.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Ret | 2018 |
The effect of inhibition of endoplasmic reticulum stress on lipolysis in white adipose tissue in a rat model of chronic kidney disease.
Topics: Acyltransferases; Adipocytes; Animals; Cells, Cultured; Disease Models, Animal; eIF-2 Kinase; Endopl | 2014 |
Endoplasmic reticulum stress inhibition limits the progression of chronic kidney disease in the Dahl salt-sensitive rat.
Topics: Animals; Blood Pressure; Disease Models, Animal; Disease Progression; Endoplasmic Reticulum Stress; | 2017 |
Endoplasmic reticulum stress inhibition attenuates hypertensive chronic kidney disease through reduction in proteinuria.
Topics: Angiotensin II; Animals; Apoptosis; Biopsy; Blood Pressure; Disease Models, Animal; Endoplasmic Reti | 2017 |