4-phenylbutyric acid has been researched along with Pulmonary Fibrosis in 2 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Pulmonary Fibrosis: A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jiang, X | 1 |
| Fang, G | 1 |
| Dong, L | 1 |
| Jin, P | 1 |
| Ding, L | 1 |
| Zhang, H | 1 |
| Fan, J | 1 |
| Mao, S | 1 |
| Fan, X | 1 |
| Gong, Y | 1 |
| Wang, Y | 1 |
| Maitra, M | 1 |
| Dey, M | 1 |
| Yuan, WC | 1 |
| Nathanielsz, PW | 1 |
| Garcia, CK | 1 |
1 trial available for 4-phenylbutyric acid and Pulmonary Fibrosis
| Article | Year |
|---|---|
Lung fibrosis-associated surfactant protein A1 and C variants induce latent transforming growth factor β1 secretion in lung epithelial cells.
Topics: Amino Acid Substitution; Animals; Antineoplastic Agents; Autocrine Communication; Cell Death; Cell L | 2013 |
1 other study available for 4-phenylbutyric acid and Pulmonary Fibrosis
| Article | Year |
|---|---|
Chemical chaperone 4-phenylbutyric acid alleviates the aggregation of human familial pulmonary fibrosis-related mutant SP-A2 protein in part through effects on GRP78.
Topics: A549 Cells; Animals; CHO Cells; Cricetulus; Dose-Response Relationship, Drug; Endoplasmic Reticulum | 2018 |