4-phenylbutyric acid has been researched along with Pulmonary Disease, Chronic Obstructive in 3 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Pulmonary Disease, Chronic Obstructive: A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chronic obstructive pulmonary disease (COPD) involves aberrant airway inflammatory responses to cigarette smoke (CS) that are associated with epithelial cell dysfunction, cilia shortening, and mucociliary clearance disruption." | 1.39 | Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction. ( An, CH; Bhashyam, AR; Biswal, SS; Cervo, M; Choi, AM; Chung, AL; Cloonan, SM; Franks, JM; Haley, KJ; Haspel, JA; Kim, HP; Lam, HC; Mahmood, A; Mizumura, K; Owen, CA; Quackenbush, J; Rahman, I; Ryter, SW; Sathirapongsasuti, JF; Shan, B; Silverman, EK; Singh, A; Tesfaigzi, Y; Washko, GR; Yao, H, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Matson, KM | 1 |
| Sonetti, DA | 1 |
| Lam, HC | 1 |
| Cloonan, SM | 1 |
| Bhashyam, AR | 1 |
| Haspel, JA | 1 |
| Singh, A | 1 |
| Sathirapongsasuti, JF | 1 |
| Cervo, M | 1 |
| Yao, H | 1 |
| Chung, AL | 1 |
| Mizumura, K | 1 |
| An, CH | 1 |
| Shan, B | 1 |
| Franks, JM | 1 |
| Haley, KJ | 1 |
| Owen, CA | 1 |
| Tesfaigzi, Y | 1 |
| Washko, GR | 1 |
| Quackenbush, J | 1 |
| Silverman, EK | 1 |
| Rahman, I | 1 |
| Kim, HP | 1 |
| Mahmood, A | 1 |
| Biswal, SS | 1 |
| Ryter, SW | 1 |
| Choi, AM | 1 |
| Gerber, V | 1 |
| Schott Ii, HC | 1 |
| Robinson, NE | 1 |
1 trial available for 4-phenylbutyric acid and Pulmonary Disease, Chronic Obstructive
| Article | Year |
|---|---|
Owner assessment in judging the efficacy of airway disease treatment.
Topics: Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Bronchoscopy; Dexamethasone; Double | 2011 |
2 other studies available for 4-phenylbutyric acid and Pulmonary Disease, Chronic Obstructive
| Article | Year |
|---|---|
Successful treatment of Ureaplasma-induced hyperammonemia syndrome post-lung transplant.
Topics: Anti-Infective Agents; Bronchoalveolar Lavage Fluid; Graft Rejection; Humans; Hyperammonemia; Immuno | 2019 |
Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction.
Topics: Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cells, Cultured; Cilia; Cytosol; Epithe | 2013 |