4-phenylbutyric acid has been researched along with Proteinuria in 4 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Proteinuria: The presence of proteins in the urine, an indicator of KIDNEY DISEASES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Proteinuria is one of the primary risk factors for the progression of chronic kidney disease (CKD) and has been implicated in the induction of endoplasmic reticulum (ER) stress." | 1.46 | Endoplasmic reticulum stress inhibition limits the progression of chronic kidney disease in the Dahl salt-sensitive rat. ( Ask, K; Brimble, E; Carlisle, RE; Chahal, J; Dickhout, JG; Lu, C; Upagupta, C; Yum, V, 2017) |
| " The dosage of 4-PBA treatment was gavaged at a dose of 1 g/kg body weight each day for 12 weeks." | 1.37 | Attenuation of diabetic nephropathy in diabetes rats induced by streptozotocin by regulating the endoplasmic reticulum stress inflammatory response. ( Feng, B; Guo, YH; Liu, L; Luo, ZF; Mu, J; Pang, Q; Qi, W; Ye, ZL; Yuan, FH; Zeng, W, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yum, V | 1 |
| Carlisle, RE | 2 |
| Lu, C | 2 |
| Brimble, E | 1 |
| Chahal, J | 1 |
| Upagupta, C | 1 |
| Ask, K | 2 |
| Dickhout, JG | 2 |
| Mohammed-Ali, Z | 1 |
| Marway, MK | 1 |
| Lukic, D | 1 |
| Krepinsky, JC | 1 |
| Luo, ZF | 2 |
| Feng, B | 2 |
| Mu, J | 2 |
| Qi, W | 2 |
| Zeng, W | 2 |
| Guo, YH | 2 |
| Pang, Q | 2 |
| Ye, ZL | 2 |
| Liu, L | 2 |
| Yuan, FH | 2 |
4 other studies available for 4-phenylbutyric acid and Proteinuria
| Article | Year |
|---|---|
Endoplasmic reticulum stress inhibition limits the progression of chronic kidney disease in the Dahl salt-sensitive rat.
Topics: Animals; Blood Pressure; Disease Models, Animal; Disease Progression; Endoplasmic Reticulum Stress; | 2017 |
Endoplasmic reticulum stress inhibition attenuates hypertensive chronic kidney disease through reduction in proteinuria.
Topics: Angiotensin II; Animals; Apoptosis; Biopsy; Blood Pressure; Disease Models, Animal; Endoplasmic Reti | 2017 |
Effects of 4-phenylbutyric acid on the process and development of diabetic nephropathy induced in rats by streptozotocin: regulation of endoplasmic reticulum stress-oxidative activation.
Topics: Animals; Antioxidants; Blood Urea Nitrogen; Creatinine; Diabetes Mellitus, Experimental; Diabetic Ne | 2010 |
Attenuation of diabetic nephropathy in diabetes rats induced by streptozotocin by regulating the endoplasmic reticulum stress inflammatory response.
Topics: Animals; Chemokine CCL2; Cytokines; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Endopla | 2011 |