4-phenylbutyric acid has been researched along with Protein Aggregation, Pathological in 3 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Protein Aggregation, Pathological: A biochemical phenomenon in which misfolded proteins aggregate either intra- or extracellularly. Triggered by factors such as MUTATION; POST-TRANSLATIONAL MODIFICATIONS, and environmental stress, it is generally associated with ALZHEIMER DISEASE; PARKINSON DISEASE; HUNTINGTON DISEASE; and TYPE 2 DIABETES MELLITUS.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Guiberson, NGL | 1 |
| Pineda, A | 1 |
| Abramov, D | 1 |
| Kharel, P | 1 |
| Carnazza, KE | 1 |
| Wragg, RT | 1 |
| Dittman, JS | 1 |
| Burré, J | 1 |
| Fan, Y | 1 |
| He, JJ | 1 |
| Upagupta, C | 1 |
| Carlisle, RE | 1 |
| Dickhout, JG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phenylbutyrate for Monogenetic Developmental and Epileptic Encephalopathy[NCT04937062] | Early Phase 1 | 50 participants (Anticipated) | Interventional | 2021-03-01 | Enrolling by invitation | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for 4-phenylbutyric acid and Protein Aggregation, Pathological
| Article | Year |
|---|---|
Mechanism-based rescue of Munc18-1 dysfunction in varied encephalopathies by chemical chaperones.
Topics: Animals; Brain Diseases; Caenorhabditis elegans Proteins; Cell Line, Tumor; Cells, Cultured; HEK293 | 2018 |
HIV-1 Tat Induces Unfolded Protein Response and Endoplasmic Reticulum Stress in Astrocytes and Causes Neurotoxicity through Glial Fibrillary Acidic Protein (GFAP) Activation and Aggregation.
Topics: Animals; Astrocytes; Brain; Cell Line, Tumor; Endoplasmic Reticulum Stress; Glial Fibrillary Acidic | 2016 |
Analysis of the potency of various low molecular weight chemical chaperones to prevent protein aggregation.
Topics: Benzothiazoles; Cell Line; Docosahexaenoic Acids; Endoplasmic Reticulum Stress; Epithelial Cells; Gl | 2017 |