4-phenylbutyric acid has been researched along with Pregnancy in 9 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Maternal obesity has been shown to increase the risk of obesity and related disorders in the offspring, which has been partially attributed to changes of appetite regulators in the offspring hypothalamus." | 1.46 | Maternal high-fat diet induces metabolic stress response disorders in offspring hypothalamus. ( Chen, H; Nguyen, LT; Pollock, C; Saad, S; Tan, Y, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 9 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nguyen, LT | 1 |
| Saad, S | 1 |
| Tan, Y | 1 |
| Pollock, C | 1 |
| Chen, H | 1 |
| Désir-Vigné, A | 1 |
| Haure-Mirande, V | 1 |
| de Coppet, P | 1 |
| Darmaun, D | 1 |
| Le Dréan, G | 1 |
| Segain, JP | 1 |
| Jara, O | 1 |
| Minogue, PJ | 1 |
| Berthoud, VM | 1 |
| Beyer, EC | 1 |
| Chen, D | 1 |
| Teng, JM | 1 |
| North, PE | 1 |
| Lapinski, PE | 1 |
| King, PD | 1 |
| Liong, S | 1 |
| Lappas, M | 1 |
| Gu, H | 1 |
| Yu, J | 1 |
| Dong, D | 1 |
| Zhou, Q | 1 |
| Wang, JY | 1 |
| Fang, S | 1 |
| Yang, P | 2 |
| Kyathanahalli, C | 1 |
| Organ, K | 1 |
| Moreci, RS | 1 |
| Anamthathmakula, P | 1 |
| Hassan, SS | 1 |
| Caritis, SN | 1 |
| Jeyasuria, P | 1 |
| Condon, JC | 1 |
| Yung, HW | 1 |
| Alnæs-Katjavivi, P | 1 |
| Jones, CJ | 1 |
| El-Bacha, T | 1 |
| Golic, M | 1 |
| Staff, AC | 1 |
| Burton, GJ | 1 |
| Li, X | 1 |
| Xu, C | 1 |
9 other studies available for 4-phenylbutyric acid and Pregnancy
| Article | Year |
|---|---|
Maternal high-fat diet induces metabolic stress response disorders in offspring hypothalamus.
Topics: Animals; Animals, Newborn; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Diet, High-Fat; | 2017 |
Perinatal supplementation of 4-phenylbutyrate and glutamine attenuates endoplasmic reticulum stress and improves colonic epithelial barrier function in rats born with intrauterine growth restriction.
Topics: Animals; Animals, Newborn; Colitis; Colon; Dietary Supplements; Endoplasmic Reticulum Stress; Epithe | 2018 |
Chemical chaperone treatment improves levels and distributions of connexins in Cx50D47A mouse lenses.
Topics: Animals; Antineoplastic Agents; Cataract; Cells, Cultured; Connexins; Female; Gene Expression Regula | 2018 |
RASA1-dependent cellular export of collagen IV controls blood and lymphatic vascular development.
Topics: Animals; Animals, Newborn; Apoptosis; Arteriovenous Malformations; Cell Line, Tumor; Collagen Type I | 2019 |
Endoplasmic reticulum stress is increased after spontaneous labor in human fetal membranes and myometrium where it regulates the expression of prolabor mediators.
Topics: Adult; Alternative Splicing; Biomarkers; Cesarean Section; DNA-Binding Proteins; Endoplasmic Reticul | 2014 |
High Glucose-Repressed CITED2 Expression Through miR-200b Triggers the Unfolded Protein Response and Endoplasmic Reticulum Stress.
Topics: 3' Untranslated Regions; Animals; Apoptosis; Blood Glucose; Diabetes Mellitus, Experimental; Embryo, | 2016 |
Uterine endoplasmic reticulum stress-unfolded protein response regulation of gestational length is caspase-3 and -7-dependent.
Topics: Analysis of Variance; Animals; Caspase 3; Caspase 7; Cell Line; DNA Primers; Endoplasmic Reticulum S | 2015 |
Placental endoplasmic reticulum stress in gestational diabetes: the potential for therapeutic intervention with chemical chaperones and antioxidants.
Topics: Acidosis; Adult; Antioxidants; Ascorbic Acid; Blood Glucose; Blotting, Western; Cell Line; Diabetes, | 2016 |
c-Jun NH2-terminal kinase 1/2 and endoplasmic reticulum stress as interdependent and reciprocal causation in diabetic embryopathy.
Topics: Animals; Apoptosis; Biomarkers; Caspase 3; Caspase 8; Diabetes Mellitus, Experimental; Endoplasmic R | 2013 |