4-phenylbutyric acid has been researched along with Precursor Cell Lymphoblastic Leukemia-Lymphoma in 2 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Precursor Cell Lymphoblastic Leukemia-Lymphoma: A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hyperammonemia has been reported following asparaginase administration, consistent with the mechanisms of asparaginase, which catabolizes asparagine to aspartic acid and ammonia, and secondarily converts glutamine to glutamate and ammonia." | 4.31 | Treatment and outcomes of symptomatic hyperammonemia following asparaginase therapy in children with acute lymphoblastic leukemia. ( Altintas, B; Eldem, I; Langley, R; Lee, A; Nguyen, H; Shinawi, M; Willis, D, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, A | 1 |
| Eldem, I | 1 |
| Altintas, B | 1 |
| Nguyen, H | 1 |
| Willis, D | 1 |
| Langley, R | 1 |
| Shinawi, M | 1 |
| Bueno, MJ | 1 |
| Pérez de Castro, I | 1 |
| Gómez de Cedrón, M | 1 |
| Santos, J | 1 |
| Calin, GA | 1 |
| Cigudosa, JC | 1 |
| Croce, CM | 1 |
| Fernández-Piqueras, J | 1 |
| Malumbres, M | 1 |
2 other studies available for 4-phenylbutyric acid and Precursor Cell Lymphoblastic Leukemia-Lymphoma
| Article | Year |
|---|---|
Treatment and outcomes of symptomatic hyperammonemia following asparaginase therapy in children with acute lymphoblastic leukemia.
Topics: Ammonia; Antineoplastic Agents; Asparaginase; Child; Glutamine; Humans; Hyperammonemia; Phenylbutyra | 2023 |
Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression.
Topics: 3' Untranslated Regions; Animals; Azacitidine; Cell Line, Tumor; Cell Proliferation; Chromosomes, Hu | 2008 |