4-phenylbutyric acid has been researched along with Polycystic Kidney Diseases in 1 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Polycystic Kidney Diseases: Hereditary diseases that are characterized by the progressive expansion of a large number of tightly packed CYSTS within the KIDNEYS. They include diseases with autosomal dominant and autosomal recessive inheritance.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sicking, M | 1 |
| Živná, M | 1 |
| Bhadra, P | 1 |
| Barešová, V | 1 |
| Tirincsi, A | 1 |
| Hadzibeganovic, D | 1 |
| Hodaňová, K | 1 |
| Vyleťal, P | 1 |
| Sovová, J | 1 |
| Jedličková, I | 1 |
| Jung, M | 1 |
| Bell, T | 1 |
| Helms, V | 1 |
| Bleyer, AJ | 1 |
| Kmoch, S | 1 |
| Cavalié, A | 1 |
| Lang, S | 1 |
1 other study available for 4-phenylbutyric acid and Polycystic Kidney Diseases
| Article | Year |
|---|---|
Phenylbutyrate rescues the transport defect of the Sec61α mutations V67G and T185A for renin.
Topics: Calcium; Endoplasmic Reticulum; HEK293 Cells; Humans; Kidney Diseases; Molecular Chaperones; Mutatio | 2022 |