4-phenylbutyric acid has been researched along with Pneumonia in 2 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Pneumonia: Infection of the lung often accompanied by inflammation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To identify the cellular mechanism of lung inflammation during lipopolysaccharide (LPS)-induced mouse model of ALI, we investigated the influence of classic ER stress inhibitor 4-phenyl butyric acid (4-PBA) on ER stress and autophagy, which partially affect the activation of inflammation, both in LPS-induced ALI mouse model and human alveolar epithelial cell model." | 1.46 | 4-PBA inhibits LPS-induced inflammation through regulating ER stress and autophagy in acute lung injury models. ( Chen, R; Chen, S; Gong, Y; Kong, X; Li, Z; Liu, Y; Sang, W; Xue, F; Zeng, M; Zhang, H, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zeng, M | 1 |
| Sang, W | 1 |
| Chen, S | 1 |
| Chen, R | 1 |
| Zhang, H | 2 |
| Xue, F | 1 |
| Li, Z | 1 |
| Liu, Y | 1 |
| Gong, Y | 1 |
| Kong, X | 1 |
| Kim, HJ | 1 |
| Jeong, JS | 1 |
| Kim, SR | 1 |
| Park, SY | 1 |
| Chae, HJ | 1 |
| Lee, YC | 1 |
2 other studies available for 4-phenylbutyric acid and Pneumonia
| Article | Year |
|---|---|
4-PBA inhibits LPS-induced inflammation through regulating ER stress and autophagy in acute lung injury models.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Autophagy; Cell Line, Tumor; Cytokines; Cytopr | 2017 |
Inhibition of endoplasmic reticulum stress alleviates lipopolysaccharide-induced lung inflammation through modulation of NF-κB/HIF-1α signaling pathway.
Topics: Animals; Biomarkers; Cell Nucleus; Cytokines; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Retic | 2013 |