4-phenylbutyric acid has been researched along with Pancreatic Neoplasms in 4 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pancreatic beta cell destruction in type 1 diabetes may be mediated by cytokines such as IL-1β, IFN-γ and TNF-α." | 1.38 | Cross-talk between the unfolded protein response and nuclear factor-κB signalling pathways regulates cytokine-mediated beta cell death in MIN6 cells and isolated mouse islets. ( Biden, TJ; Chan, JY; Laybutt, DR, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Welsch, L | 1 |
| Welsch, T | 1 |
| Dovzhanskiy, DI | 2 |
| Felix, K | 2 |
| Giese, NA | 1 |
| Krysko, DV | 2 |
| Werner, J | 2 |
| Chan, JY | 1 |
| Biden, TJ | 1 |
| Laybutt, DR | 1 |
| Hartwig, W | 1 |
| Lázár, NG | 1 |
| Schmidt, A | 1 |
| Straub, BK | 1 |
| Hackert, T | 1 |
| Ammerpohl, O | 1 |
| Trauzold, A | 1 |
| Schniewind, B | 1 |
| Griep, U | 1 |
| Pilarsky, C | 1 |
| Grutzmann, R | 1 |
| Saeger, HD | 1 |
| Janssen, O | 1 |
| Sipos, B | 1 |
| Kloppel, G | 1 |
| Kalthoff, H | 1 |
4 other studies available for 4-phenylbutyric acid and Pancreatic Neoplasms
| Article | Year |
|---|---|
Impact of the histone deacetylase inhibitor 4-phenylbutyrate on the clearance of apoptotic pancreatic carcinoma cells by human macrophages.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Carcinoma, Pancreatic Ductal; Cel | 2012 |
Cross-talk between the unfolded protein response and nuclear factor-κB signalling pathways regulates cytokine-mediated beta cell death in MIN6 cells and isolated mouse islets.
Topics: Animals; Antineoplastic Agents; Cell Death; Cell Line, Tumor; Cell Survival; Cytokines; Diabetes Mel | 2012 |
Growth inhibition of pancreatic cancer by experimental treatment with 4-phenylbutyrate is associated with increased expression of Connexin 43.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Cell Proliferation; Connexin 43; Fluorescent Anti | 2012 |
Complementary effects of HDAC inhibitor 4-PB on gap junction communication and cellular export mechanisms support restoration of chemosensitivity of PDAC cells.
Topics: Anthracenes; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Pancreatic Ductal | 2007 |