4-phenylbutyric acid has been researched along with Ornithine Carbamoyltransferase Deficiency Disease in 3 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Ornithine Carbamoyltransferase Deficiency Disease: An inherited urea cycle disorder associated with deficiency of the enzyme ORNITHINE CARBAMOYLTRANSFERASE, transmitted as an X-linked trait and featuring elevations of amino acids and ammonia in the serum. Clinical features, which are more prominent in males, include seizures, behavioral alterations, episodic vomiting, lethargy, and coma. (Menkes, Textbook of Child Neurology, 5th ed, pp49-50)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Zhou, D | 1 |
| Shang, X | 1 |
| Qiao, Y | 1 |
| Cheng, Y | 1 |
| Yu, Z | 1 |
| Huang, X | 1 |
| Hayashi, H | 1 |
| Mizuno, T | 1 |
| Horikawa, R | 1 |
| Nagasaka, H | 1 |
| Yabuki, T | 1 |
| Takikawa, H | 1 |
| Sugiyama, Y | 1 |
1 review available for 4-phenylbutyric acid and Ornithine Carbamoyltransferase Deficiency Disease
| Article | Year |
|---|---|
[Preliminary study of glyceryl phenylbutyrate therapy for Ornithine transcarbamylase deficiency and a literature review].
Topics: Ammonia; Child; Humans; Ornithine Carbamoyltransferase Deficiency Disease; Phenylbutyrates; Retrospe | 2023 |
2 other studies available for 4-phenylbutyric acid and Ornithine Carbamoyltransferase Deficiency Disease
| Article | Year |
|---|---|
4-Phenylbutyrate modulates ubiquitination of hepatocanalicular MRP2 and reduces serum total bilirubin concentration.
Topics: Adult; Animals; Bilirubin; Carcinoma, Hepatocellular; Cell Line; Cell Membrane; Child, Preschool; Do | 2012 |
Sodium phenylbutyrate for urea cycle enzyme deficiencies.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Costs and Cost Analysis; Female; Humans; Infant; Liver; | 1996 |