4-phenylbutyric acid has been researched along with Obesity in 17 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| " It is suggested that chronic ER stress is associated with obesity and leptin resistance." | 4.02 | Chemical Chaperone PBA Attenuates ER Stress and Upregulates SOCS3 Expression as a Regulator of Leptin Signaling. ( Baba, B; Boyuk, G; Caliskan, M; Hacisevki, A, 2021) |
| " Moreover, the mRNA expression of ET-1 was significantly increased in cultured HAECs in response to acute (< 24 h) and chronic (12-16 days) treatments with palmitic acid (PA), one of the most abundant saturated fatty acids in obesity." | 3.88 | Palmitic Acid Increases Endothelin-1 Expression in Vascular Endothelial Cells through the Induction of Endoplasmic Reticulum Stress and Protein Kinase C Signaling. ( Wang, X; Xu, L; Yang, XC; Zhang, J; Zhao, WS, 2018) |
| "Leptin has not evolved as a therapeutic modality for the treatment of obesity due to the prevalence of leptin resistance in a majority of the obese population." | 3.75 | Endoplasmic reticulum stress plays a central role in development of leptin resistance. ( Chung, J; Ergin, AS; Lu, A; Myers, MG; Nie, D; Ozcan, L; Ozcan, U; Sarkar, S, 2009) |
| "Maternal obesity has been shown to increase the risk of obesity and related disorders in the offspring, which has been partially attributed to changes of appetite regulators in the offspring hypothalamus." | 1.46 | Maternal high-fat diet induces metabolic stress response disorders in offspring hypothalamus. ( Chen, H; Nguyen, LT; Pollock, C; Saad, S; Tan, Y, 2017) |
| " Exercise induces AMPK activation and subsequent PPARδ activation, which help to reduce endoplasmic reticulum (ER) and oxidative stress, thus increasing NO bioavailability in endothelial cells and vascular tissues." | 1.46 | PPARδ Is Required for Exercise to Attenuate Endoplasmic Reticulum Stress and Endothelial Dysfunction in Diabetic Mice. ( Cheang, WS; Chen, ZY; Huang, Y; Lau, CW; Ma, RC; Tian, XY; Wang, L; Wang, N; Wong, WT; Xu, A; Xu, J; Zhao, L, 2017) |
| "RETRACTED: Obesity is a significant risk factor for acute respiratory distress syndrome." | 1.46 | Obesity-Induced Endoplasmic Reticulum Stress Causes Lung Endothelial Dysfunction and Promotes Acute Lung Injury. ( Guo, Z; Kallen, CB; Li, J; Naik, UP; Romero, F; Shah, D; Summer, R; Sun, J, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (17.65) | 29.6817 |
| 2010's | 12 (70.59) | 24.3611 |
| 2020's | 2 (11.76) | 2.80 |
| Authors | Studies |
|---|---|
| Min, BK | 1 |
| Kang, HJ | 1 |
| Choi, BJ | 1 |
| Jeon, YH | 1 |
| Cho, JY | 1 |
| Lee, IK | 1 |
| Kim, DW | 1 |
| Baba, B | 1 |
| Caliskan, M | 1 |
| Boyuk, G | 1 |
| Hacisevki, A | 1 |
| de Pablo, S | 1 |
| Rodríguez-Comas, J | 1 |
| Díaz-Catalán, D | 1 |
| Alcarraz-Vizán, G | 1 |
| Castaño, C | 1 |
| Moreno-Vedia, J | 1 |
| Montane, J | 1 |
| Parrizas, M | 1 |
| Servitja, JM | 1 |
| Novials, A | 1 |
| Nguyen, LT | 1 |
| Saad, S | 1 |
| Tan, Y | 1 |
| Pollock, C | 1 |
| Chen, H | 1 |
| Liu, Y | 2 |
| Chen, Y | 1 |
| Zhang, J | 2 |
| Zhang, Y | 1 |
| Su, Z | 1 |
| Ulum, B | 1 |
| Teker, HT | 1 |
| Sarikaya, A | 1 |
| Balta, G | 1 |
| Kuskonmaz, B | 1 |
| Uckan-Cetinkaya, D | 1 |
| Aerts-Kaya, F | 1 |
| Zhao, WS | 1 |
| Wang, X | 1 |
| Xu, L | 1 |
| Yang, XC | 1 |
| Townsend, LK | 1 |
| Medak, KD | 1 |
| Peppler, WT | 1 |
| Meers, GM | 1 |
| Rector, RS | 1 |
| LeBlanc, PJ | 1 |
| Wright, DC | 1 |
| Song, G | 1 |
| Wu, X | 1 |
| Zhang, P | 1 |
| Yu, Y | 1 |
| Yang, M | 1 |
| Jiao, P | 1 |
| Wang, N | 2 |
| Song, H | 1 |
| Wu, Y | 1 |
| Zhang, X | 1 |
| Liu, H | 1 |
| Qin, S | 1 |
| Cheang, WS | 1 |
| Wong, WT | 1 |
| Zhao, L | 1 |
| Xu, J | 1 |
| Wang, L | 1 |
| Lau, CW | 1 |
| Chen, ZY | 1 |
| Ma, RC | 1 |
| Xu, A | 1 |
| Tian, XY | 1 |
| Huang, Y | 1 |
| Shah, D | 1 |
| Romero, F | 1 |
| Guo, Z | 1 |
| Sun, J | 1 |
| Li, J | 1 |
| Kallen, CB | 1 |
| Naik, UP | 1 |
| Summer, R | 1 |
| Ozcan, L | 1 |
| Ergin, AS | 1 |
| Lu, A | 1 |
| Chung, J | 1 |
| Sarkar, S | 1 |
| Nie, D | 1 |
| Myers, MG | 1 |
| Ozcan, U | 1 |
| Lawless, MW | 1 |
| O'Byrne, KJ | 1 |
| Gray, SG | 1 |
| Xu, TY | 1 |
| Chen, RH | 1 |
| Wang, P | 1 |
| Zhang, RY | 1 |
| Ke, SF | 1 |
| Miao, CY | 1 |
| Koh, IU | 1 |
| Lim, JH | 1 |
| Joe, MK | 1 |
| Kim, WH | 1 |
| Jung, MH | 1 |
| Yoon, JB | 1 |
| Song, J | 1 |
| Chan, JY | 1 |
| Luzuriaga, J | 1 |
| Bensellam, M | 1 |
| Biden, TJ | 1 |
| Laybutt, DR | 1 |
| Gregor, MF | 1 |
| Hotamisligil, GS | 1 |
2 reviews available for 4-phenylbutyric acid and Obesity
| Article | Year |
|---|---|
Histone deacetylase inhibitors target diabetes via chromatin remodeling or as chemical chaperones?
Topics: Acetyltransferases; Chromatin Assembly and Disassembly; Diabetes Mellitus, Type 2; Drug Delivery Sys | 2009 |
Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease.
Topics: Adipocytes; Animals; Cholesterol; Endoplasmic Reticulum; Humans; Inflammation; Lipid Metabolism; Met | 2007 |
15 other studies available for 4-phenylbutyric acid and Obesity
| Article | Year |
|---|---|
Phenylbutyrate Ameliorates High-Fat Diet-Induced Obesity via Brown Adipose Tissue Activation.
Topics: Adipocytes; Adipose Tissue, Brown; Animals; Anti-Obesity Agents; Diet, High-Fat; Disease Models, Ani | 2019 |
Chemical Chaperone PBA Attenuates ER Stress and Upregulates SOCS3 Expression as a Regulator of Leptin Signaling.
Topics: Animals; Endoplasmic Reticulum Stress; Gene Expression Regulation; Leptin; Male; Mice; Mice, Inbred | 2021 |
4-Phenylbutyrate (PBA) treatment reduces hyperglycemia and islet amyloid in a mouse model of type 2 diabetes and obesity.
Topics: Amyloid; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal | 2021 |
Maternal high-fat diet induces metabolic stress response disorders in offspring hypothalamus.
Topics: Animals; Animals, Newborn; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Diet, High-Fat; | 2017 |
Retinoic acid receptor-related orphan receptor α stimulates adipose tissue inflammation by modulating endoplasmic reticulum stress.
Topics: 3T3-L1 Cells; Adipocytes, White; Animals; Anti-Obesity Agents; Benzamides; Endoplasmic Reticulum Str | 2017 |
Bone marrow mesenchymal stem cell donors with a high body mass index display elevated endoplasmic reticulum stress and are functionally impaired.
Topics: Activating Transcription Factor 4; Adipogenesis; Adolescent; Adult; Alkaline Phosphatase; Body Mass | 2018 |
Palmitic Acid Increases Endothelin-1 Expression in Vascular Endothelial Cells through the Induction of Endoplasmic Reticulum Stress and Protein Kinase C Signaling.
Topics: Animals; Cells, Cultured; Diet, High-Fat; Endoplasmic Reticulum Stress; Endothelial Cells; Endotheli | 2018 |
High-saturated-fat diet-induced obesity causes hepatic interleukin-6 resistance via endoplasmic reticulum stress.
Topics: Animals; Diet, High-Fat; Dietary Fats; Endoplasmic Reticulum Stress; Glucose; Glucose Intolerance; H | 2019 |
High-density lipoprotein inhibits ox-LDL-induced adipokine secretion by upregulating SR-BI expression and suppressing ER Stress pathway.
Topics: 3T3-L1 Cells; Activating Transcription Factor 6; Adipokines; Animals; CD36 Antigens; Cholesterol, HD | 2016 |
PPARδ Is Required for Exercise to Attenuate Endoplasmic Reticulum Stress and Endothelial Dysfunction in Diabetic Mice.
Topics: Animals; Aorta; Blood Pressure; Diabetes Mellitus; Diabetic Angiopathies; Diet, High-Fat; Endoplasmi | 2017 |
Obesity-Induced Endoplasmic Reticulum Stress Causes Lung Endothelial Dysfunction and Promotes Acute Lung Injury.
Topics: Activating Transcription Factor 6; Acute Lung Injury; Animals; Cell Adhesion Molecules; Dietary Fats | 2017 |
Endoplasmic reticulum stress plays a central role in development of leptin resistance.
Topics: Animals; Endoplasmic Reticulum; Hypothalamus; Leptin; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity | 2009 |
4-Phenyl butyric acid does not generally reduce glucose levels in rodent models of diabetes.
Topics: Animals; Blood Glucose; Blood Proteins; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; | 2010 |
AdipoR2 is transcriptionally regulated by ER stress-inducible ATF3 in HepG2 human hepatocyte cells.
Topics: Activating Transcription Factor 3; Animals; Chromatin Immunoprecipitation; DNA; Electrophoretic Mobi | 2010 |
Failure of the adaptive unfolded protein response in islets of obese mice is linked with abnormalities in β-cell gene expression and progression to diabetes.
Topics: Animals; Antioxidants; Apoptosis Regulatory Proteins; Cytokines; Diabetes Mellitus, Type 2; Disease | 2013 |