4-phenylbutyric acid has been researched along with Neurodegenerative Diseases in 5 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Neurodegenerative Diseases: Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In familial Parkinson's disease, accumulation of Parkin-associated endothelin receptor-like receptor (Pael-R), a substrate of ubiquitin ligase Parkin involved in ERAD, leads to ER stress and apoptosis." | 2.48 | [Molecular pharmacological studies on the protection mechanism against endoplasmic reticulum stress-induced neurodegenerative disease]. ( Kaneko, M, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alfahel, L | 1 |
| Argueti-Ostrovsky, S | 1 |
| Barel, S | 1 |
| Ali Saleh, M | 1 |
| Kahn, J | 1 |
| Azoulay-Ginsburg, S | 1 |
| Rothstein, A | 1 |
| Ebbinghaus, S | 1 |
| Gruzman, A | 1 |
| Israelson, A | 1 |
| Kusaczuk, M | 1 |
| Bartoszewicz, M | 1 |
| Cechowska-Pasko, M | 1 |
| Mimori, S | 1 |
| Okuma, Y | 2 |
| Kaneko, M | 3 |
| Kawada, K | 1 |
| Hosoi, T | 1 |
| Ozawa, K | 1 |
| Nomura, Y | 1 |
| Hamana, H | 1 |
| Inden, M | 1 |
| Kitamura, Y | 1 |
| Takeuchi, H | 1 |
| Yanagida, T | 1 |
| Takata, K | 1 |
| Kobayashi, Y | 1 |
| Taniguchi, T | 1 |
| Yoshimoto, K | 1 |
| Taira, T | 1 |
| Ariga, H | 1 |
| Shimohama, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phenylbutyrate for Monogenetic Developmental and Epileptic Encephalopathy[NCT04937062] | Early Phase 1 | 50 participants (Anticipated) | Interventional | 2021-03-01 | Enrolling by invitation | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for 4-phenylbutyric acid and Neurodegenerative Diseases
| Article | Year |
|---|---|
Phenylbutyric Acid: simple structure - multiple effects.
Topics: Animals; Apoptosis; Colonic Neoplasms; Humans; Neurodegenerative Diseases; Phenylbutyrates | 2015 |
[Molecular pharmacological studies on the protection mechanism against endoplasmic reticulum stress-induced neurodegenerative disease].
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Apoptosis; Brain; Endoplasmic Reticulum | 2012 |
3 other studies available for 4-phenylbutyric acid and Neurodegenerative Diseases
| Article | Year |
|---|---|
4-Phenylbutyric Acid (4-PBA) Derivatives Prevent SOD1 Amyloid Aggregation In Vitro with No Effect on Disease Progression in SOD1-ALS Mice.
Topics: Amyloid; Amyloidogenic Proteins; Amyotrophic Lateral Sclerosis; Animals; Butylamines; Disease Models | 2022 |
Protective effects of 4-phenylbutyrate derivatives on the neuronal cell death and endoplasmic reticulum stress.
Topics: Animals; Carbon; Cattle; Cell Death; Cell Line, Tumor; Cell Survival; Endoplasmic Reticulum Chaperon | 2012 |
Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone.
Topics: alpha-Synuclein; Animals; Cells, Cultured; Corpus Striatum; Disease Models, Animal; Dopamine; Endopl | 2007 |