4-phenylbutyric acid has been researched along with Neuralgia in 2 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Neuralgia: Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated the effects of 4-PBA on neuropathic pain associated with VPN induced by ischaemia-reperfusion (IR) and its underlying mechanisms." | 1.51 | 4-Phenylbutyric acid protects against vasculitic peripheral neuropathy induced by ischaemia-reperfusion through attenuating endoplasmic reticulum stress. ( Chen, CH; Chuang, CW; Kao, MC; Lin, HY; Pan, PT; Shih, PC; Wang, PK, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, CH | 1 |
| Shih, PC | 1 |
| Lin, HY | 1 |
| Wang, PK | 1 |
| Pan, PT | 1 |
| Chuang, CW | 1 |
| Kao, MC | 1 |
| Inceoglu, B | 1 |
| Bettaieb, A | 1 |
| Trindade da Silva, CA | 1 |
| Lee, KS | 1 |
| Haj, FG | 1 |
| Hammock, BD | 1 |
2 other studies available for 4-phenylbutyric acid and Neuralgia
| Article | Year |
|---|---|
4-Phenylbutyric acid protects against vasculitic peripheral neuropathy induced by ischaemia-reperfusion through attenuating endoplasmic reticulum stress.
Topics: Animals; Biomarkers; Endoplasmic Reticulum Stress; Inflammation; Male; Neuralgia; NF-kappa B; Periph | 2019 |
Endoplasmic reticulum stress in the peripheral nervous system is a significant driver of neuropathic pain.
Topics: Animals; Apoptosis; Autophagy; Blood Glucose; Blotting, Western; Diabetes Mellitus, Experimental; Di | 2015 |