4-phenylbutyric acid has been researched along with Muscular Diseases in 3 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Muscular Diseases: Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hayashi, G | 1 |
| Labelle-Dumais, C | 2 |
| Gould, DB | 2 |
| Zito, E | 1 |
| Kuo, DS | 1 |
| Mao, M | 1 |
| Jeanne, M | 1 |
| Kauffman, WB | 1 |
| Allen, J | 1 |
| Favor, J | 1 |
1 review available for 4-phenylbutyric acid and Muscular Diseases
| Article | Year |
|---|---|
Targeting ER stress/ER stress response in myopathies.
Topics: Activating Transcription Factor 6; Adenine; Aldehydes; Animals; eIF-2 Kinase; Endoplasmic Reticulum; | 2019 |
2 other studies available for 4-phenylbutyric acid and Muscular Diseases
| Article | Year |
|---|---|
Use of sodium 4-phenylbutyrate to define therapeutic parameters for reducing intracerebral hemorrhage and myopathy in
Topics: Aging; Animals; Animals, Newborn; Cerebral Hemorrhage; Collagen Type IV; Female; Male; Mice, Inbred | 2018 |
Allelic heterogeneity contributes to variability in ocular dysgenesis, myopathy and brain malformations caused by Col4a1 and Col4a2 mutations.
Topics: Alleles; Animals; Antineoplastic Agents; Basement Membrane; Brain; Cells, Cultured; Collagen Type IV | 2014 |