4-phenylbutyric acid has been researched along with Muscular Atrophy in 5 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Muscular Atrophy: Derangement in size and number of muscle fibers occurring with aging, reduction in blood supply, or following immobilization, prolonged weightlessness, malnutrition, and particularly in denervation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cachexia is a devastating syndrome that causes morbidity and mortality in a large number of patients with cancer." | 1.43 | Inhibition of ER stress and unfolding protein response pathways causes skeletal muscle wasting during cancer cachexia. ( Bohnert, KR; Gallot, YS; Hindi, SM; Kumar, A; Sato, S; Xiong, G, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Braun, D | 3 |
| Bohleber, S | 1 |
| Vatine, GD | 1 |
| Svendsen, CN | 1 |
| Schweizer, U | 3 |
| Reddy, SS | 1 |
| Shruthi, K | 1 |
| Joy, D | 1 |
| Reddy, GB | 1 |
| Bohnert, KR | 1 |
| Gallot, YS | 1 |
| Sato, S | 1 |
| Xiong, G | 1 |
| Hindi, SM | 1 |
| Kumar, A | 1 |
5 other studies available for 4-phenylbutyric acid and Muscular Atrophy
| Article | Year |
|---|---|
Sodium Phenylbutyrate Rescues Thyroid Hormone Transport in Brain Endothelial-Like Cells.
Topics: Biological Transport; Brain; Humans; Mental Retardation, X-Linked; Monocarboxylic Acid Transporters; | 2022 |
4-PBA prevents diabetic muscle atrophy in rats by modulating ER stress response and ubiquitin-proteasome system.
Topics: Animals; Apoptosis; Biomarkers; Diabetes Mellitus, Experimental; Endoplasmic Reticulum Stress; Injec | 2019 |
Efficient Activation of Pathogenic ΔPhe501 Mutation in Monocarboxylate Transporter 8 by Chemical and Pharmacological Chaperones.
Topics: Animals; Cell Membrane; Cysteine Proteinase Inhibitors; Dimethyl Sulfoxide; Dogs; Genistein; Iodine | 2015 |
Inhibition of ER stress and unfolding protein response pathways causes skeletal muscle wasting during cancer cachexia.
Topics: Activating Transcription Factor 6; Adenomatous Polyposis Coli Protein; AMP-Activated Protein Kinases | 2016 |
The Chemical Chaperone Phenylbutyrate Rescues MCT8 Mutations Associated With Milder Phenotypes in Patients With Allan-Herndon-Dudley Syndrome.
Topics: Animals; Antineoplastic Agents; Chlorocebus aethiops; Dogs; Drug Evaluation, Preclinical; Genistein; | 2017 |