4-phenylbutyric acid has been researched along with Mucositis, Oral in 2 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "5-Fluorouracil (5-FU)-induced oral mucositis has a severe negative impact on the patient's quality of life." | 1.72 | Protective effect of endoplasmic reticulum stress inhibition on 5-fluorouracil-induced oral mucositis. ( Cao, YN; Chen, C; Hou, Y; Li, M; Shan, E; Shan, J; Wang, J; Wang, Y; Zhang, L; Zhou, Y, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cao, YN | 1 |
| Wang, Y | 1 |
| Zhang, L | 1 |
| Hou, Y | 1 |
| Shan, J | 1 |
| Li, M | 1 |
| Chen, C | 1 |
| Zhou, Y | 1 |
| Shan, E | 1 |
| Wang, J | 1 |
| Chung, YL | 1 |
| Lee, MY | 1 |
| Pui, NN | 1 |
2 other studies available for 4-phenylbutyric acid and Mucositis, Oral
| Article | Year |
|---|---|
Protective effect of endoplasmic reticulum stress inhibition on 5-fluorouracil-induced oral mucositis.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Endoplasmic Reticulum Stress; Fluorouracil; | 2022 |
Epigenetic therapy using the histone deacetylase inhibitor for increasing therapeutic gain in oral cancer: prevention of radiation-induced oral mucositis and inhibition of chemical-induced oral carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetylation; Administration, Oral; Animals; Antineoplastic Agents; | 2009 |