4-phenylbutyric acid has been researched along with Mental Retardation, X-Linked in 5 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Mental Retardation, X-Linked: A class of genetic disorders resulting in INTELLECTUAL DISABILITY that is associated either with mutations of GENES located on the X CHROMOSOME or aberrations in the structure of the X chromosome (SEX CHROMOSOME ABERRATIONS).
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Braun, D | 3 |
| Bohleber, S | 1 |
| Vatine, GD | 1 |
| Svendsen, CN | 1 |
| Schweizer, U | 3 |
| Salazar, MD | 1 |
| Zelt, NB | 1 |
| Saldivar, R | 1 |
| Kuntz, CP | 1 |
| Chen, S | 1 |
| Penn, WD | 1 |
| Bonneau, R | 1 |
| Koehler Leman, J | 1 |
| Schlebach, JP | 1 |
| El-Kasaby, A | 1 |
| Kasture, A | 1 |
| Koban, F | 1 |
| Hotka, M | 1 |
| Asjad, HMM | 1 |
| Kubista, H | 1 |
| Freissmuth, M | 1 |
| Sucic, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phenylbutyrate for Monogenetic Developmental and Epileptic Encephalopathy[NCT04937062] | Early Phase 1 | 50 participants (Anticipated) | Interventional | 2021-03-01 | Enrolling by invitation | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 other studies available for 4-phenylbutyric acid and Mental Retardation, X-Linked
| Article | Year |
|---|---|
Sodium Phenylbutyrate Rescues Thyroid Hormone Transport in Brain Endothelial-Like Cells.
Topics: Biological Transport; Brain; Humans; Mental Retardation, X-Linked; Monocarboxylic Acid Transporters; | 2022 |
Classification of the Molecular Defects Associated with Pathogenic Variants of the
Topics: Brain Diseases, Metabolic, Inborn; Creatine; HEK293 Cells; Humans; Membrane Transport Proteins; Ment | 2020 |
Rescue by 4-phenylbutyrate of several misfolded creatine transporter-1 variants linked to the creatine transporter deficiency syndrome.
Topics: Animals; Brain Diseases, Metabolic, Inborn; Calnexin; Cell Membrane; Creatine; Endoplasmic Reticulum | 2019 |
Efficient Activation of Pathogenic ΔPhe501 Mutation in Monocarboxylate Transporter 8 by Chemical and Pharmacological Chaperones.
Topics: Animals; Cell Membrane; Cysteine Proteinase Inhibitors; Dimethyl Sulfoxide; Dogs; Genistein; Iodine | 2015 |
The Chemical Chaperone Phenylbutyrate Rescues MCT8 Mutations Associated With Milder Phenotypes in Patients With Allan-Herndon-Dudley Syndrome.
Topics: Animals; Antineoplastic Agents; Chlorocebus aethiops; Dogs; Drug Evaluation, Preclinical; Genistein; | 2017 |