4-phenylbutyric acid has been researched along with Memory Disorders in 3 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Memory Disorders: Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yao, ZH | 1 |
| Kang, X | 1 |
| Yang, L | 1 |
| Niu, Y | 1 |
| Lu, Y | 1 |
| Gong, CX | 2 |
| Tian, Q | 2 |
| Wang, JZ | 2 |
| Yao, Z | 1 |
| Guo, Z | 1 |
| Yang, C | 1 |
| Liu, G | 1 |
| Ricobaraza, A | 1 |
| Cuadrado-Tejedor, M | 1 |
| Marco, S | 1 |
| Pérez-Otaño, I | 1 |
| García-Osta, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pharmacokinetic and Pharmacodynamic Study of AMX0035 in Patients With ALS[NCT04987671] | Phase 1/Phase 2 | 14 participants (Anticipated) | Interventional | 2021-08-05 | Active, not recruiting | ||
| Phenylbutyrate for Monogenetic Developmental and Epileptic Encephalopathy[NCT04937062] | Early Phase 1 | 50 participants (Anticipated) | Interventional | 2021-03-01 | Enrolling by invitation | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for 4-phenylbutyric acid and Memory Disorders
| Article | Year |
|---|---|
Phenylbutyric acid protects against spatial memory deficits in a model of repeated electroconvulsive therapy.
Topics: Animals; Blotting, Western; Brain; Disease Models, Animal; Electroconvulsive Therapy; Long-Term Pote | 2014 |
Phenylbutyric acid prevents rats from electroconvulsion-induced memory deficit with alterations of memory-related proteins and tau hyperphosphorylation.
Topics: Animals; Brain; Cell Count; Cyclic AMP Response Element-Binding Protein; Disks Large Homolog 4 Prote | 2010 |
Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Animals; CA1 Region, Hippocampal; Dendritic S | 2012 |
Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Animals; CA1 Region, Hippocampal; Dendritic S | 2012 |
Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Animals; CA1 Region, Hippocampal; Dendritic S | 2012 |
Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Animals; CA1 Region, Hippocampal; Dendritic S | 2012 |