4-phenylbutyric acid has been researched along with Liver Neoplasms in 11 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Liver Neoplasms: Tumors or cancer of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "However, its role in hepatocarcinogenesis remained unknown." | 5.62 | 4-phenylbutyric acid promotes hepatocellular carcinoma via initiating cancer stem cells through activation of PPAR-α. ( Cao, QQ; Chen, C; Chen, SZ; Chen, XF; Dong, YP; Fan, ZC; Ling, Y; Miao, YS; Monga, SPS; Song, YT; Tang, JJ; Tao, JY; Wang, HY; Wen, W; Yu, H; Yu, LX, 2021) |
| "However, its role in hepatocarcinogenesis remained unknown." | 1.62 | 4-phenylbutyric acid promotes hepatocellular carcinoma via initiating cancer stem cells through activation of PPAR-α. ( Cao, QQ; Chen, C; Chen, SZ; Chen, XF; Dong, YP; Fan, ZC; Ling, Y; Miao, YS; Monga, SPS; Song, YT; Tang, JJ; Tao, JY; Wang, HY; Wen, W; Yu, H; Yu, LX, 2021) |
| "METHODS; Hepatocellular carcinoma cells Bel-7402 and normal liver cell line L-02 were treated with NaPB at different concentrations." | 1.35 | Growth inhibition and gene induction in human hepatocellular carcinoma cell exposed to sodium 4-phenylbutanoate. ( Jiang, JJ; Jiang, JM; Jin, CJ; Meng, M; Qin, CY; Ren, HS; Wang, CT; Yu, DQ; Zhang, JC, 2008) |
| "Fenofibrate treatment preserved AdipoR2 and phosphorylated AMPK (pAMPK) levels in palmitate-treated cells accompanied by reduced triglyceride (TG) accumulation and less activation of ER stress markers CCAAT/enhancer binding (C/EBPbeta) and eukaryotic translation initiation factor 2 alpha." | 1.35 | Fenofibrate and PBA prevent fatty acid-induced loss of adiponectin receptor and pAMPK in human hepatoma cells and in hepatitis C virus-induced steatosis. ( Friedman, JE; Janssen, RC; Qadri, I; Rahman, SM, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 7 (63.64) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, SZ | 1 |
| Ling, Y | 1 |
| Yu, LX | 1 |
| Song, YT | 1 |
| Chen, XF | 1 |
| Cao, QQ | 1 |
| Yu, H | 1 |
| Chen, C | 1 |
| Tang, JJ | 1 |
| Fan, ZC | 1 |
| Miao, YS | 1 |
| Dong, YP | 1 |
| Tao, JY | 1 |
| Monga, SPS | 1 |
| Wen, W | 1 |
| Wang, HY | 1 |
| Nissar, AU | 1 |
| Sharma, L | 1 |
| Mudasir, MA | 1 |
| Nazir, LA | 1 |
| Umar, SA | 1 |
| Sharma, PR | 1 |
| Vishwakarma, RA | 1 |
| Tasduq, SA | 1 |
| Tanaka, T | 1 |
| Kojima, K | 1 |
| Yokota, K | 1 |
| Tanaka, Y | 1 |
| Ooizumi, Y | 1 |
| Ishii, S | 1 |
| Nishizawa, N | 1 |
| Yokoi, K | 1 |
| Ushiku, H | 1 |
| Kikuchi, M | 1 |
| Kojo, K | 1 |
| Minatani, N | 1 |
| Katoh, H | 1 |
| Sato, T | 1 |
| Nakamura, T | 1 |
| Sawanobori, M | 1 |
| Watanabe, M | 1 |
| Yamashita, K | 1 |
| Song, K | 1 |
| Han, C | 1 |
| Zhang, J | 1 |
| Lu, D | 1 |
| Dash, S | 1 |
| Feitelson, M | 1 |
| Lim, K | 1 |
| Wu, T | 1 |
| Bender, HU | 1 |
| Staudigl, M | 1 |
| Schmid, I | 1 |
| Führer, M | 1 |
| Liu, J | 2 |
| Han, P | 1 |
| Li, M | 1 |
| Yan, W | 1 |
| He, J | 1 |
| Gong, J | 1 |
| Wang, Y | 1 |
| Tian, D | 1 |
| Roberts, JL | 1 |
| He, B | 1 |
| Erickson, A | 1 |
| Moreau, R | 1 |
| Wang, CT | 1 |
| Meng, M | 1 |
| Zhang, JC | 1 |
| Jin, CJ | 1 |
| Jiang, JJ | 1 |
| Ren, HS | 1 |
| Jiang, JM | 1 |
| Qin, CY | 1 |
| Yu, DQ | 1 |
| Rahman, SM | 1 |
| Qadri, I | 1 |
| Janssen, RC | 1 |
| Friedman, JE | 1 |
| Hayashi, H | 1 |
| Mizuno, T | 1 |
| Horikawa, R | 1 |
| Nagasaka, H | 1 |
| Yabuki, T | 1 |
| Takikawa, H | 1 |
| Sugiyama, Y | 1 |
| Svechnikova, I | 1 |
| Gray, SG | 1 |
| Kundrotiene, J | 1 |
| Ponthan, F | 1 |
| Kogner, P | 1 |
| Ekström, TJ | 1 |
11 other studies available for 4-phenylbutyric acid and Liver Neoplasms
| Article | Year |
|---|---|
4-phenylbutyric acid promotes hepatocellular carcinoma via initiating cancer stem cells through activation of PPAR-α.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Liver Neoplasms; Male; Mice; Mice, Inbred C57BL; | 2021 |
Chemical chaperone 4-phenyl butyric acid (4-PBA) reduces hepatocellular lipid accumulation and lipotoxicity through induction of autophagy.
Topics: Autophagy; Autophagy-Related Protein 7; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Cell | 2017 |
Comprehensive Genetic Search to Clarify the Molecular Mechanism of Drug Resistance Identifies ASCL2-LEF1/TSPAN8 Axis in Colorectal Cancer.
Topics: Antineoplastic Agents; Basic Helix-Loop-Helix Transcription Factors; Biomarkers, Tumor; Colorectal N | 2019 |
Epigenetic regulation of MicroRNA-122 by peroxisome proliferator activated receptor-gamma and hepatitis b virus X protein in hepatocellular carcinoma cells.
Topics: Azacitidine; Carcinoma, Hepatocellular; Decitabine; Epigenesis, Genetic; Hep G2 Cells; Hepatitis C; | 2013 |
Treatment of Paraneoplastic Hyperammonemia in Fibrolamellar Hepatocellular Carcinoma With Oral Sodium Phenylbutyrate.
Topics: Administration, Oral; Antineoplastic Agents; Carcinoma, Hepatocellular; Fatal Outcome; Female; Human | 2015 |
Histidine-rich calcium binding protein promotes growth of hepatocellular carcinoma in vitro and in vivo.
Topics: Activating Transcription Factor 4; Animals; Apoptosis; Calcium-Binding Proteins; Carcinoma, Hepatoce | 2015 |
Improvement of mTORC1-driven overproduction of apoB-containing triacylglyceride-rich lipoproteins by short-chain fatty acids, 4-phenylbutyric acid and (R)-α-lipoic acid, in human hepatocellular carcinoma cells.
Topics: Adaptor Proteins, Signal Transducing; Apolipoprotein B-100; Carcinoma, Hepatocellular; Carrier Prote | 2016 |
Growth inhibition and gene induction in human hepatocellular carcinoma cell exposed to sodium 4-phenylbutanoate.
Topics: Antineoplastic Agents; Blotting, Western; Cadherins; Carcinoma, Hepatocellular; Cell Cycle; Cell Lin | 2008 |
Fenofibrate and PBA prevent fatty acid-induced loss of adiponectin receptor and pAMPK in human hepatoma cells and in hepatitis C virus-induced steatosis.
Topics: AMP-Activated Protein Kinases; Blotting, Western; Carcinoma, Hepatocellular; CCAAT-Enhancer-Binding | 2009 |
4-Phenylbutyrate modulates ubiquitination of hepatocanalicular MRP2 and reduces serum total bilirubin concentration.
Topics: Adult; Animals; Bilirubin; Carcinoma, Hepatocellular; Cell Line; Cell Membrane; Child, Preschool; Do | 2012 |
Apoptosis and tumor remission in liver tumor xenografts by 4-phenylbutyrate.
Topics: Acetylation; alpha-Fetoproteins; Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellula | 2003 |