4-phenylbutyric acid has been researched along with Liver Dysfunction in 5 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tietz Bogert, PS | 1 |
| Huang, BQ | 1 |
| Gradilone, SA | 1 |
| Masyuk, TV | 1 |
| Moulder, GL | 1 |
| Ekker, SC | 1 |
| Larusso, NF | 1 |
| Zhou, H | 1 |
| Zhu, J | 1 |
| Yue, S | 1 |
| Lu, L | 1 |
| Busuttil, RW | 1 |
| Kupiec-Weglinski, JW | 1 |
| Wang, X | 1 |
| Zhai, Y | 1 |
| Nagamani, SC | 1 |
| Erez, A | 1 |
| Lee, B | 1 |
| Teckman, JH | 1 |
| Hanada, S | 1 |
| Harada, M | 1 |
| Kumemura, H | 1 |
| Bishr Omary, M | 1 |
| Koga, H | 1 |
| Kawaguchi, T | 1 |
| Taniguchi, E | 1 |
| Yoshida, T | 1 |
| Hisamoto, T | 1 |
| Yanagimoto, C | 1 |
| Maeyama, M | 1 |
| Ueno, T | 1 |
| Sata, M | 1 |
1 review available for 4-phenylbutyric acid and Liver Dysfunction
| Article | Year |
|---|---|
Argininosuccinate lyase deficiency.
Topics: Arginine; Argininosuccinate Lyase; Argininosuccinic Acid; Argininosuccinic Aciduria; Child, Preschoo | 2012 |
4 other studies available for 4-phenylbutyric acid and Liver Dysfunction
| Article | Year |
|---|---|
The zebrafish as a model to study polycystic liver disease.
Topics: Animals; Antineoplastic Agents; Calcium-Binding Proteins; Cysts; Disease Models, Animal; DNA Helicas | 2013 |
The Dichotomy of Endoplasmic Reticulum Stress Response in Liver Ischemia-Reperfusion Injury.
Topics: Activating Transcription Factors; Adenine; AMP-Activated Protein Kinases; Animals; Autophagy; Autoph | 2016 |
Lack of effect of oral 4-phenylbutyrate on serum alpha-1-antitrypsin in patients with alpha-1-antitrypsin deficiency: a preliminary study.
Topics: Administration, Oral; Adolescent; Adult; alpha 1-Antitrypsin; alpha 1-Antitrypsin Deficiency; Child; | 2004 |
Oxidative stress induces the endoplasmic reticulum stress and facilitates inclusion formation in cultured cells.
Topics: Cysteine Proteinase Inhibitors; Endoplasmic Reticulum; Fluoresceins; Glucose Oxidase; Humans; Hydrog | 2007 |