4-phenylbutyric acid has been researched along with Liver Cirrhosis in 4 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Eriksen, PL | 1 |
| Djernes, L | 1 |
| Vilstrup, H | 1 |
| Ott, P | 1 |
| Weiss, N | 1 |
| Tripon, S | 1 |
| Lodey, M | 1 |
| Guiller, E | 1 |
| Junot, H | 1 |
| Monneret, D | 1 |
| Mayaux, J | 1 |
| Brisson, H | 1 |
| Mallet, M | 1 |
| Rudler, M | 1 |
| Imbert-Bismut, F | 1 |
| Thabut, D | 1 |
| Carrier, P | 1 |
| Loustaud-Ratti, V | 1 |
| Henkel, AS | 1 |
| Dewey, AM | 1 |
| Anderson, KA | 1 |
| Olivares, S | 1 |
| Green, RM | 1 |
1 trial available for 4-phenylbutyric acid and Liver Cirrhosis
| Article | Year |
|---|---|
Clearance and production of ammonia quantified in humans by constant ammonia infusion - the effects of cirrhosis and ammonia-targeting treatments.
Topics: Ammonia; Hepatic Encephalopathy; Humans; Hyperammonemia; Lactulose; Liver Cirrhosis; Male; Phenylbut | 2023 |
3 other studies available for 4-phenylbutyric acid and Liver Cirrhosis
| Article | Year |
|---|---|
Treating hepatic encephalopathy in cirrhotic patients admitted to ICU with sodium phenylbutyrate: a preliminary study.
Topics: Aged; Ammonia; Biomarkers; Case-Control Studies; Female; Hepatic Encephalopathy; Hospital Mortality; | 2018 |
Treating hepatic encephalopathy in cirrhotic patients admitted to ICU with sodium phenylbutyrate: a preliminary study.
Topics: Hepatic Encephalopathy; Humans; Intensive Care Units; Liver Cirrhosis; Phenylbutyrates | 2018 |
Reducing endoplasmic reticulum stress does not improve steatohepatitis in mice fed a methionine- and choline-deficient diet.
Topics: Animals; Blood Glucose; Blotting, Western; Body Weight; Cholesterol; Choline Deficiency; Diet; Endop | 2012 |