4-phenylbutyric acid has been researched along with Leukemia, Myeloid in 3 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Leukemia, Myeloid: Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Successful treatment of acute promyelocytic leukemia (APL) has identified several novel approaches to induce leukemic cell differentiation and selective apoptosis by overcoming the site-specific transcriptional repression by dominant fusion leukemogenic proteins characteristic of APL and other forms of acute myelogenous leukemia (AML)." | 2.41 | Differentiation therapy in acute myelogenous leukemia (non-APL). ( Waxman, S, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Maslak, P | 1 |
| Chanel, S | 1 |
| Camacho, LH | 1 |
| Soignet, S | 1 |
| Pandolfi, PP | 1 |
| Guernah, I | 1 |
| Warrell, R | 1 |
| Nimer, S | 1 |
| Ryningen, A | 1 |
| Stapnes, C | 1 |
| Bruserud, Ø | 1 |
| Waxman, S | 1 |
1 review available for 4-phenylbutyric acid and Leukemia, Myeloid
| Article | Year |
|---|---|
Differentiation therapy in acute myelogenous leukemia (non-APL).
Topics: Acute Disease; Adult; Aged; Animals; Antineoplastic Agents; Apoptosis; Butyrates; Cell Differentiati | 2000 |
1 trial available for 4-phenylbutyric acid and Leukemia, Myeloid
| Article | Year |
|---|---|
Pilot study of combination transcriptional modulation therapy with sodium phenylbutyrate and 5-azacytidine in patients with acute myeloid leukemia or myelodysplastic syndrome.
Topics: Acetylation; Acute Disease; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Aza | 2006 |
1 other study available for 4-phenylbutyric acid and Leukemia, Myeloid
| Article | Year |
|---|---|
Clonogenic acute myelogenous leukemia cells are heterogeneous with regard to regulation of differentiation and effect of epigenetic pharmacological targeting.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Apoptosis; Azacitidine; Cell C | 2007 |