4-phenylbutyric acid has been researched along with Leukemia, Erythroblastic, Acute in 1 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Leukemia, Erythroblastic, Acute: A myeloproliferative disorder characterized by neoplastic proliferation of erythroblastic and myeloblastic elements with atypical erythroblasts and myeloblasts in the peripheral blood.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lea, MA | 1 |
| Shareef, A | 1 |
| Sura, M | 1 |
| desBordes, C | 1 |
1 other study available for 4-phenylbutyric acid and Leukemia, Erythroblastic, Acute
| Article | Year |
|---|---|
Induction of histone acetylation and inhibition of growth by phenyl alkanoic acids and structurally related molecules.
Topics: Acetylation; Animals; Apoptosis; Cell Division; Cell Line; Colonic Neoplasms; Histones; Humans; Leuk | 2004 |