4-phenylbutyric acid has been researched along with Kidney Diseases in 4 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Kidney Diseases: Pathological processes of the KIDNEY or its component tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Renal fibrosis is a potent predictor of progression in patients and is often accompanied by inflammation and oxidative stress; however, the mechanisms involved in these alterations are not well established." | 1.62 | Role of endoplasmic reticulum stress in renal damage after myocardial infarction. ( Cachofeiro, V; de la Fuente-Chávez, L; Delgado-Valero, B; Islas, F; Luaces, M; Martínez-Martínez, E; Ramchandani, B; Romero-Miranda, A; Visitación Bartolomé, M, 2021) |
| "Hyperoxaluria-associated deposition of calcium oxalate crystals results from oxalate-induced renal injury and inflammation." | 1.51 | Modulatory effect of 4-phenyl butyric acid on hyperoxaluria-induced renal injury and inflammation. ( Naura, AS; Sharma, M; Singla, SK, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 2 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sicking, M | 1 |
| Živná, M | 1 |
| Bhadra, P | 1 |
| Barešová, V | 1 |
| Tirincsi, A | 1 |
| Hadzibeganovic, D | 1 |
| Hodaňová, K | 1 |
| Vyleťal, P | 1 |
| Sovová, J | 1 |
| Jedličková, I | 1 |
| Jung, M | 1 |
| Bell, T | 1 |
| Helms, V | 1 |
| Bleyer, AJ | 1 |
| Kmoch, S | 1 |
| Cavalié, A | 1 |
| Lang, S | 1 |
| Delgado-Valero, B | 1 |
| de la Fuente-Chávez, L | 1 |
| Romero-Miranda, A | 1 |
| Visitación Bartolomé, M | 1 |
| Ramchandani, B | 1 |
| Islas, F | 1 |
| Luaces, M | 1 |
| Cachofeiro, V | 1 |
| Martínez-Martínez, E | 1 |
| Sharma, M | 1 |
| Naura, AS | 1 |
| Singla, SK | 1 |
| Kemter, E | 1 |
| Sklenak, S | 1 |
| Rathkolb, B | 1 |
| Hrabě de Angelis, M | 1 |
| Wolf, E | 1 |
| Aigner, B | 1 |
| Wanke, R | 1 |
4 other studies available for 4-phenylbutyric acid and Kidney Diseases
| Article | Year |
|---|---|
Phenylbutyrate rescues the transport defect of the Sec61α mutations V67G and T185A for renin.
Topics: Calcium; Endoplasmic Reticulum; HEK293 Cells; Humans; Kidney Diseases; Molecular Chaperones; Mutatio | 2022 |
Role of endoplasmic reticulum stress in renal damage after myocardial infarction.
Topics: Adult; Animals; Cells, Cultured; Disease Models, Animal; Endoplasmic Reticulum Stress; Female; Fibro | 2021 |
Modulatory effect of 4-phenyl butyric acid on hyperoxaluria-induced renal injury and inflammation.
Topics: Animals; Antineoplastic Agents; Biomarkers; Hyperoxaluria; Inflammation; Kidney Diseases; Male; Oxid | 2019 |
No amelioration of uromodulin maturation and trafficking defect by sodium 4-phenylbutyrate in vivo: studies in mouse models of uromodulin-associated kidney disease.
Topics: Animals; Cytoplasm; Disease Models, Animal; Gout; Homozygote; HSP70 Heat-Shock Proteins; Hyperuricem | 2014 |