4-phenylbutyric acid has been researched along with Invasiveness, Neoplasm in 3 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clear cell renal cell carcinoma (ccRCC) is the most common type of cancer of the renal parenchyma." | 1.42 | Upregulation of microRNA-492 induced by epigenetic drug treatment inhibits the malignant phenotype of clear cell renal cell carcinoma in vitro. ( Bao, L; Li, J; Li, M; Li, S; Shen, X; Wu, A; Wu, K; Yang, Z, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, A | 1 |
| Wu, K | 1 |
| Li, M | 1 |
| Bao, L | 1 |
| Shen, X | 1 |
| Li, S | 1 |
| Li, J | 1 |
| Yang, Z | 1 |
| He, C | 1 |
| Zhao, X | 1 |
| Jiang, H | 1 |
| Zhong, Z | 1 |
| Xu, R | 1 |
| Engelhard, HH | 1 |
| Homer, RJ | 1 |
| Duncan, HA | 1 |
| Rozental, J | 1 |
3 other studies available for 4-phenylbutyric acid and Invasiveness, Neoplasm
| Article | Year |
|---|---|
Upregulation of microRNA-492 induced by epigenetic drug treatment inhibits the malignant phenotype of clear cell renal cell carcinoma in vitro.
Topics: Apoptosis; Biomarkers, Tumor; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Proliferation; CpG Islan | 2015 |
Demethylation of miR-10b plays a suppressive role in ccRCC cells.
Topics: Azacitidine; Carcinoma, Renal Cell; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; | 2015 |
Inhibitory effects of phenylbutyrate on the proliferation, morphology, migration and invasiveness of malignant glioma cells.
Topics: Apoptosis; Cell Cycle; Cell Division; Cell Movement; Glioblastoma; Humans; Neoplasm Invasiveness; Ph | 1998 |