4-phenylbutyric acid has been researched along with Inflammation in 26 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lewisite is a potent arsenic-based chemical warfare agent known to induce painful cutaneous inflammation and blistering." | 7.83 | Molecular Mechanism Underlying Pathogenesis of Lewisite-Induced Cutaneous Blistering and Inflammation: Chemical Chaperones as Potential Novel Antidotes. ( Afaq, F; Agarwal, A; Athar, M; Croutch, CR; Elmets, CA; Li, C; Srivastava, RK; Weng, Z, 2016) |
| "Olanzapine treatment for 8 days in rats was associated with activated PERK-eIF2α signaling and IKKβ-NFκB signaling in the hypothalamus, accompanied by increased food intake and weight gain." | 5.51 | Olanzapine-induced endoplasmic reticulum stress and inflammation in the hypothalamus were inhibited by an ER stress inhibitor 4-phenylbutyrate. ( Chen, J; Gao, G; He, M; Hu, J; Huang, XF; Li, J; Li, W; Sun, T; Zhou, T, 2019) |
| " By using the streptomycin-treated mouse model, we found that Taconic mice treated with PBA exhibited significantly lower S Typhimurium intestinal colonization and dissemination to the reticuloendothelial system, as well as lower levels of inflammation." | 3.83 | Beneficial Effects of Sodium Phenylbutyrate Administration during Infection with Salmonella enterica Serovar Typhimurium. ( Behnsen, J; Edwards, RA; Gao, N; Jellbauer, S; Murphy, C; Nguyen, T; Perez Lopez, A; Raffatellu, M, 2016) |
| "Lewisite is a potent arsenic-based chemical warfare agent known to induce painful cutaneous inflammation and blistering." | 3.83 | Molecular Mechanism Underlying Pathogenesis of Lewisite-Induced Cutaneous Blistering and Inflammation: Chemical Chaperones as Potential Novel Antidotes. ( Afaq, F; Agarwal, A; Athar, M; Croutch, CR; Elmets, CA; Li, C; Srivastava, RK; Weng, Z, 2016) |
| " In vivo, the induction of ER stress by ischemia-reperfusion and the impact of ER stress amelioration by a small molecule chaperon 4-phenylbutyric acid on liver immune response were studied in a murine partial liver warm ischemia model." | 3.78 | Endoplasmic reticulum stress modulates liver inflammatory immune response in the pathogenesis of liver ischemia and reperfusion injury. ( Bai, L; Busuttil, RW; Cheng, Q; Gao, F; Kupiec-Weglinski, JW; Liu, J; Ren, F; Shen, X; Zhai, Y, 2012) |
| "Hyperoxaluria-associated deposition of calcium oxalate crystals results from oxalate-induced renal injury and inflammation." | 1.51 | Modulatory effect of 4-phenyl butyric acid on hyperoxaluria-induced renal injury and inflammation. ( Naura, AS; Sharma, M; Singla, SK, 2019) |
| "Olanzapine treatment for 8 days in rats was associated with activated PERK-eIF2α signaling and IKKβ-NFκB signaling in the hypothalamus, accompanied by increased food intake and weight gain." | 1.51 | Olanzapine-induced endoplasmic reticulum stress and inflammation in the hypothalamus were inhibited by an ER stress inhibitor 4-phenylbutyrate. ( Chen, J; Gao, G; He, M; Hu, J; Huang, XF; Li, J; Li, W; Sun, T; Zhou, T, 2019) |
| "We investigated the effects of 4-PBA on neuropathic pain associated with VPN induced by ischaemia-reperfusion (IR) and its underlying mechanisms." | 1.51 | 4-Phenylbutyric acid protects against vasculitic peripheral neuropathy induced by ischaemia-reperfusion through attenuating endoplasmic reticulum stress. ( Chen, CH; Chuang, CW; Kao, MC; Lin, HY; Pan, PT; Shih, PC; Wang, PK, 2019) |
| "Type 2 diabetes is a chronic inflammatory disease." | 1.46 | Endoplasmic reticulum stress induced by lipopolysaccharide is involved in the association between inflammation and autophagy in INS‑1 cells. ( Cao, MM; Li, YB; Liu, GD; Liu, H; Su, Y; Yin, JJ, 2017) |
| "Adipose tissue inflammation has been linked to age-related metabolic diseases." | 1.42 | Elevated Endoplasmic Reticulum Stress Response Contributes to Adipose Tissue Inflammation in Aging. ( Garg, SK; Ghosh, AK; Liu, J; Mau, T; O'Brien, M; Yung, R, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (3.85) | 29.6817 |
| 2010's | 22 (84.62) | 24.3611 |
| 2020's | 3 (11.54) | 2.80 |
| Authors | Studies |
|---|---|
| Saunders, MJ | 1 |
| Edwards, BS | 1 |
| Zhu, J | 1 |
| Sklar, LA | 1 |
| Graves, SW | 1 |
| Yadav, A | 1 |
| Huang, TC | 1 |
| Chen, SH | 1 |
| Ramasamy, TS | 1 |
| Hsueh, YY | 1 |
| Lin, SP | 1 |
| Lu, FI | 1 |
| Liu, YH | 1 |
| Wu, CC | 1 |
| Huang, Y | 1 |
| Yuan, M | 1 |
| Duan, F | 1 |
| Yang, Y | 1 |
| Lou, B | 1 |
| Lin, X | 1 |
| Choi, Y | 1 |
| Lee, EG | 1 |
| Jeong, JH | 1 |
| Yoo, WH | 1 |
| Liu, H | 1 |
| Yin, JJ | 1 |
| Cao, MM | 1 |
| Liu, GD | 1 |
| Su, Y | 1 |
| Li, YB | 1 |
| Tang, YH | 1 |
| Yue, ZS | 1 |
| Zheng, WJ | 1 |
| Shen, HF | 1 |
| Zeng, LR | 1 |
| Hu, ZQ | 1 |
| Xiong, ZF | 1 |
| Sharma, M | 1 |
| Naura, AS | 1 |
| Singla, SK | 1 |
| He, M | 1 |
| Huang, XF | 1 |
| Gao, G | 1 |
| Zhou, T | 1 |
| Li, W | 1 |
| Hu, J | 1 |
| Chen, J | 1 |
| Li, J | 2 |
| Sun, T | 1 |
| Chen, CH | 1 |
| Shih, PC | 1 |
| Lin, HY | 1 |
| Wang, PK | 1 |
| Pan, PT | 1 |
| Chuang, CW | 1 |
| Kao, MC | 1 |
| Cai, Z | 1 |
| Li, F | 1 |
| Gong, W | 1 |
| Liu, W | 1 |
| Duan, Q | 1 |
| Chen, C | 1 |
| Ni, L | 1 |
| Xia, Y | 1 |
| Cianflone, K | 1 |
| Dong, N | 1 |
| Wang, DW | 1 |
| Makhija, L | 1 |
| Krishnan, V | 1 |
| Rehman, R | 1 |
| Chakraborty, S | 1 |
| Maity, S | 1 |
| Mabalirajan, U | 1 |
| Chakraborty, K | 1 |
| Ghosh, B | 1 |
| Agrawal, A | 1 |
| Zeng, W | 1 |
| Guo, YH | 1 |
| Qi, W | 1 |
| Chen, JG | 1 |
| Yang, LL | 1 |
| Luo, ZF | 1 |
| Mu, J | 1 |
| Feng, B | 1 |
| Ghosh, AK | 1 |
| Garg, SK | 1 |
| Mau, T | 1 |
| O'Brien, M | 1 |
| Liu, J | 2 |
| Yung, R | 1 |
| Kulkarni, NN | 1 |
| Yi, Z | 1 |
| Huehnken, C | 1 |
| Agerberth, B | 1 |
| Gudmundsson, GH | 1 |
| Ren, F | 2 |
| Zhou, L | 1 |
| Zhang, X | 1 |
| Wen, T | 1 |
| Shi, H | 1 |
| Xie, B | 1 |
| Li, Z | 1 |
| Chen, D | 1 |
| Wang, Z | 1 |
| Duan, Z | 1 |
| Jangra, A | 1 |
| Sriram, CS | 1 |
| Dwivedi, S | 1 |
| Gurjar, SS | 1 |
| Hussain, MI | 1 |
| Borah, P | 1 |
| Lahkar, M | 1 |
| Jellbauer, S | 1 |
| Perez Lopez, A | 1 |
| Behnsen, J | 1 |
| Gao, N | 1 |
| Nguyen, T | 1 |
| Murphy, C | 1 |
| Edwards, RA | 1 |
| Raffatellu, M | 1 |
| Li, C | 2 |
| Srivastava, RK | 2 |
| Weng, Z | 2 |
| Croutch, CR | 1 |
| Agarwal, A | 2 |
| Elmets, CA | 2 |
| Afaq, F | 2 |
| Athar, M | 2 |
| Qaisiya, M | 1 |
| Brischetto, C | 1 |
| Jašprová, J | 1 |
| Vitek, L | 1 |
| Tiribelli, C | 1 |
| Bellarosa, C | 1 |
| Mohammed-Ali, Z | 1 |
| Lu, C | 1 |
| Marway, MK | 1 |
| Carlisle, RE | 1 |
| Ask, K | 1 |
| Lukic, D | 1 |
| Krepinsky, JC | 1 |
| Dickhout, JG | 1 |
| Mukai, S | 1 |
| Ogawa, Y | 1 |
| Urano, F | 1 |
| Kudo-Saito, C | 1 |
| Kawakami, Y | 1 |
| Tsubota, K | 1 |
| Henkel, AS | 1 |
| Dewey, AM | 1 |
| Anderson, KA | 1 |
| Olivares, S | 1 |
| Green, RM | 1 |
| Cheng, Q | 1 |
| Bai, L | 1 |
| Shen, X | 1 |
| Gao, F | 1 |
| Busuttil, RW | 1 |
| Kupiec-Weglinski, JW | 1 |
| Zhai, Y | 1 |
| Wang, JQ | 1 |
| Chen, X | 1 |
| Zhang, C | 1 |
| Tao, L | 1 |
| Zhang, ZH | 1 |
| Liu, XQ | 1 |
| Xu, YB | 1 |
| Wang, H | 1 |
| Xu, DX | 1 |
| Gregor, MF | 1 |
| Hotamisligil, GS | 1 |
1 review available for 4-phenylbutyric acid and Inflammation
| Article | Year |
|---|---|
Thematic review series: Adipocyte Biology. Adipocyte stress: the endoplasmic reticulum and metabolic disease.
Topics: Adipocytes; Animals; Cholesterol; Endoplasmic Reticulum; Humans; Inflammation; Lipid Metabolism; Met | 2007 |
25 other studies available for 4-phenylbutyric acid and Inflammation
| Article | Year |
|---|---|
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr | 2010 |
Sodium phenylbutyrate inhibits Schwann cell inflammation via HDAC and NFκB to promote axonal regeneration and remyelination.
Topics: Animals; Axons; Cell Line; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Inflammatio | 2021 |
Inhibition of endoplasmic reticulum stress by 4-phenylbutyrate alleviates retinal inflammation and the apoptosis of retinal ganglion cells after ocular alkali burn in mice.
Topics: Animals; Apoptosis; Burns, Chemical; Disease Models, Animal; Endoplasmic Reticulum Stress; Inflammat | 2022 |
4-Phenylbutyric acid, a potent endoplasmic reticulum stress inhibitor, attenuates the severity of collagen-induced arthritis in mice via inhibition of proliferation and inflammatory responses of synovial fibroblasts.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Bone and Bones; Cell Proliferation; Cell Su | 2021 |
Endoplasmic reticulum stress induced by lipopolysaccharide is involved in the association between inflammation and autophagy in INS‑1 cells.
Topics: Activating Transcription Factor 4; Adenine; Animals; Apoptosis; Autophagy; Caspase 1; Cell Count; Ce | 2017 |
4-Phenylbutyric acid presents therapeutic effect on osteoarthritis via inhibiting cell apoptosis and inflammatory response induced by endoplasmic reticulum stress.
Topics: Animals; Apoptosis; Endoplasmic Reticulum Stress; Inflammation; Male; Osteoarthritis; Phenylbutyrate | 2018 |
Modulatory effect of 4-phenyl butyric acid on hyperoxaluria-induced renal injury and inflammation.
Topics: Animals; Antineoplastic Agents; Biomarkers; Hyperoxaluria; Inflammation; Kidney Diseases; Male; Oxid | 2019 |
Olanzapine-induced endoplasmic reticulum stress and inflammation in the hypothalamus were inhibited by an ER stress inhibitor 4-phenylbutyrate.
Topics: Animals; Antipsychotic Agents; Cell Line, Tumor; eIF-2 Kinase; Endoplasmic Reticulum; Endoplasmic Re | 2019 |
4-Phenylbutyric acid protects against vasculitic peripheral neuropathy induced by ischaemia-reperfusion through attenuating endoplasmic reticulum stress.
Topics: Animals; Biomarkers; Endoplasmic Reticulum Stress; Inflammation; Male; Neuralgia; NF-kappa B; Periph | 2019 |
Endoplasmic reticulum stress participates in aortic valve calcification in hypercholesterolemic animals.
Topics: Aged; Animals; Aortic Valve; Aortic Valve Stenosis; Apolipoproteins E; Calcinosis; Calcium; Cell Dif | 2013 |
Chemical chaperones mitigate experimental asthma by attenuating endoplasmic reticulum stress.
Topics: Airway Remodeling; Animals; Asthma; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Glycerol; I | 2014 |
4-Phenylbutyric acid suppresses inflammation through regulation of endoplasmic reticulum stress of endothelial cells stimulated by uremic serum.
Topics: Cell Proliferation; Chemokine CCL2; Culture Media; Endoplasmic Reticulum Chaperone BiP; Endoplasmic | 2014 |
Elevated Endoplasmic Reticulum Stress Response Contributes to Adipose Tissue Inflammation in Aging.
Topics: Activating Transcription Factor 6; Adipose Tissue; Age Factors; Animals; Cell Culture Techniques; Cy | 2015 |
Phenylbutyrate induces cathelicidin expression via the vitamin D receptor: Linkage to inflammatory and growth factor cytokines pathways.
Topics: Antimicrobial Cationic Peptides; beta-Defensins; Cathelicidins; Cell Line; Cholecalciferol; Cytokine | 2015 |
Endoplasmic reticulum stress-activated glycogen synthase kinase 3β aggravates liver inflammation and hepatotoxicity in mice with acute liver failure.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Apoptosis; Aspartate Aminotransferases; End | 2015 |
Sodium Phenylbutyrate and Edaravone Abrogate Chronic Restraint Stress-Induced Behavioral Deficits: Implication of Oxido-Nitrosative, Endoplasmic Reticulum Stress Cascade, and Neuroinflammation.
Topics: Animals; Antipyrine; Chronic Disease; Depression; Dose-Response Relationship, Drug; Edaravone; Endop | 2017 |
Beneficial Effects of Sodium Phenylbutyrate Administration during Infection with Salmonella enterica Serovar Typhimurium.
Topics: Animals; Disease Models, Animal; Immunity, Mucosal; Inflammation; Interleukin-17; Interleukin-23; In | 2016 |
Molecular Mechanism Underlying Pathogenesis of Lewisite-Induced Cutaneous Blistering and Inflammation: Chemical Chaperones as Potential Novel Antidotes.
Topics: Acetylcysteine; Animals; Antidotes; Antioxidants; Arsenicals; Blister; Chemical Warfare Agents; Dise | 2016 |
Bilirubin-induced ER stress contributes to the inflammatory response and apoptosis in neuronal cells.
Topics: Animals; Apoptosis; Astrocytoma; Bilirubin; Caspase 3; Cell Differentiation; Cell Line, Tumor; Cell | 2017 |
Defining cutaneous molecular pathobiology of arsenicals using phenylarsine oxide as a prototype.
Topics: Animals; Arsenicals; Cell Line; Cells, Cultured; Edema; Endoplasmic Reticulum Chaperone BiP; Erythem | 2016 |
Endoplasmic reticulum stress inhibition attenuates hypertensive chronic kidney disease through reduction in proteinuria.
Topics: Angiotensin II; Animals; Apoptosis; Biopsy; Blood Pressure; Disease Models, Animal; Endoplasmic Reti | 2017 |
Novel Treatment of Chronic Graft-Versus-Host Disease in Mice Using the ER Stress Reducer 4-Phenylbutyric Acid.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Chronic Disease; Disease Models, Animal; Endoplasmi | 2017 |
Reducing endoplasmic reticulum stress does not improve steatohepatitis in mice fed a methionine- and choline-deficient diet.
Topics: Animals; Blood Glucose; Blotting, Western; Body Weight; Cholesterol; Choline Deficiency; Diet; Endop | 2012 |
Endoplasmic reticulum stress modulates liver inflammatory immune response in the pathogenesis of liver ischemia and reperfusion injury.
Topics: Animals; Endoplasmic Reticulum; Gene Expression Regulation; Hepatocytes; Immune System; Inflammation | 2012 |
Phenylbutyric acid protects against carbon tetrachloride-induced hepatic fibrogenesis in mice.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum Stress; | 2013 |