4-phenylbutyric acid has been researched along with Hypoxia in 8 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the effect of 4-phenylbutyric acid (4-PBA) on intermittent hypoxia (IH)-induced liver cell injury and to clarify the underlying mechanisms." | 7.91 | 4-phenylbutyric acid attenuates endoplasmic reticulum stress-mediated apoptosis and protects the hepatocytes from intermittent hypoxia-induced injury. ( Fan, W; Qiang, Z; Tingting, D; Xin, L; Zuoming, S, 2019) |
| "To investigate the effect of 4-phenylbutyric acid (4-PBA) on intermittent hypoxia (IH)-induced liver cell injury and to clarify the underlying mechanisms." | 3.91 | 4-phenylbutyric acid attenuates endoplasmic reticulum stress-mediated apoptosis and protects the hepatocytes from intermittent hypoxia-induced injury. ( Fan, W; Qiang, Z; Tingting, D; Xin, L; Zuoming, S, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xiang, BQ | 1 |
| Gao, H | 1 |
| Chen, XW | 1 |
| Dai, YY | 1 |
| Wang, WT | 1 |
| Xin, L | 1 |
| Fan, W | 1 |
| Tingting, D | 1 |
| Zuoming, S | 1 |
| Qiang, Z | 1 |
| Koyama, M | 1 |
| Furuhashi, M | 1 |
| Ishimura, S | 1 |
| Mita, T | 1 |
| Fuseya, T | 1 |
| Okazaki, Y | 1 |
| Yoshida, H | 1 |
| Tsuchihashi, K | 1 |
| Miura, T | 1 |
| Tung, WF | 1 |
| Chen, WJ | 1 |
| Hung, HC | 1 |
| Liu, GY | 1 |
| Tung, JN | 1 |
| Huang, CC | 1 |
| Lin, CL | 1 |
| Xu, LH | 1 |
| Xie, H | 1 |
| Shi, ZH | 1 |
| Du, LD | 1 |
| Wing, YK | 1 |
| Li, AM | 1 |
| Ke, Y | 1 |
| Yung, WH | 1 |
| Jain, K | 1 |
| Suryakumar, G | 1 |
| Ganju, L | 1 |
| Singh, SB | 1 |
| Hattori, S | 1 |
| Kamiya, T | 1 |
| Hara, H | 1 |
| Ninomiya, M | 1 |
| Koketsu, M | 1 |
| Adachi, T | 1 |
| Dromparis, P | 1 |
| Paulin, R | 1 |
| Stenson, TH | 1 |
| Haromy, A | 1 |
| Sutendra, G | 1 |
| Michelakis, ED | 1 |
8 other studies available for 4-phenylbutyric acid and Hypoxia
| Article | Year |
|---|---|
[Excessive endoplasmic reticulum stress mediates brain damage in hypoxia hypercapnia induced pulmonary hypertension rats].
Topics: Animals; Apoptosis; Brain; Brain Injuries; Caspase 12; Caspase 3; Endoplasmic Reticulum Stress; Heat | 2017 |
4-phenylbutyric acid attenuates endoplasmic reticulum stress-mediated apoptosis and protects the hepatocytes from intermittent hypoxia-induced injury.
Topics: Apoptosis; Cell Survival; Cells, Cultured; Endoplasmic Reticulum; Hepatocytes; Humans; Hypoxia; Phen | 2019 |
Reduction of endoplasmic reticulum stress by 4-phenylbutyric acid prevents the development of hypoxia-induced pulmonary arterial hypertension.
Topics: Animals; Blood Pressure; Cells, Cultured; Cytokines; DNA-Binding Proteins; Endoplasmic Reticulum Cha | 2014 |
4-Phenylbutyric Acid (4-PBA) and Lithium Cooperatively Attenuate Cell Death during Oxygen-Glucose Deprivation (OGD) and Reoxygenation.
Topics: Brain Ischemia; Cell Death; Cells, Cultured; Drug Synergism; Endoplasmic Reticulum Stress; Glucose; | 2015 |
Critical Role of Endoplasmic Reticulum Stress in Chronic Intermittent Hypoxia-Induced Deficits in Synaptic Plasticity and Long-Term Memory.
Topics: Animals; Caspase 3; Endoplasmic Reticulum Stress; Hippocampus; Hypoxia; Male; Memory; Memory, Long-T | 2015 |
Amelioration of ER stress by 4-phenylbutyric acid reduces chronic hypoxia induced cardiac damage and improves hypoxic tolerance through upregulation of HIF-1α.
Topics: Altitude; Animals; Apoptosis; Apoptosis Regulatory Proteins; Chronic Disease; Cytoprotection; Diseas | 2016 |
CoCl
Topics: Acetylation; Animals; Chlorocebus aethiops; Cobalt; COS Cells; Epigenesis, Genetic; Flavonoids; Hist | 2016 |
Attenuating endoplasmic reticulum stress as a novel therapeutic strategy in pulmonary hypertension.
Topics: Activating Transcription Factor 6; Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Ch | 2013 |