4-phenylbutyric acid has been researched along with Hypothyroidism in 2 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Hypothyroidism: A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA. It may be primary or secondary due to other pituitary disease, or hypothalamic dysfunction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Methimazole (MMI) was applied to construct a noninvasive SCH mouse model." | 1.43 | Endoplasmic Reticulum Stress May Play a Pivotal Role in Lipid Metabolic Disorders in a Novel Mouse Model of Subclinical Hypothyroidism. ( Bo, T; Chen, W; Ding, S; Gao, L; Li, C; Li, Y; Liu, X; Wang, L; Wu, K; Xu, C; Zhao, J; Zhou, L, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, X | 1 |
| Shao, S | 1 |
| Zhao, L | 1 |
| Yang, R | 1 |
| Zhao, M | 1 |
| Fang, L | 1 |
| Li, M | 1 |
| Chen, W | 2 |
| Song, Y | 1 |
| Xu, C | 2 |
| Zhou, X | 1 |
| Zhao, J | 2 |
| Gao, L | 2 |
| Zhou, L | 1 |
| Ding, S | 1 |
| Li, Y | 1 |
| Wang, L | 1 |
| Bo, T | 1 |
| Wu, K | 1 |
| Li, C | 1 |
| Liu, X | 1 |
2 other studies available for 4-phenylbutyric acid and Hypothyroidism
| Article | Year |
|---|---|
ER stress contributes to high-fat diet-induced decrease of thyroglobulin and hypothyroidism.
Topics: Animals; Diet, High-Fat; Dietary Fats; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Humans; | 2019 |
Endoplasmic Reticulum Stress May Play a Pivotal Role in Lipid Metabolic Disorders in a Novel Mouse Model of Subclinical Hypothyroidism.
Topics: Animals; Disease Models, Animal; Endoplasmic Reticulum Stress; Humans; Hypothyroidism; Lipid Metabol | 2016 |