4-phenylbutyric acid has been researched along with Hypertension, Pulmonary in 6 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Hypertension, Pulmonary: Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xiang, BQ | 1 |
| Gao, H | 1 |
| Chen, XW | 1 |
| Dai, YY | 1 |
| Wang, WT | 1 |
| Koyama, M | 1 |
| Furuhashi, M | 1 |
| Ishimura, S | 1 |
| Mita, T | 1 |
| Fuseya, T | 1 |
| Okazaki, Y | 1 |
| Yoshida, H | 1 |
| Tsuchihashi, K | 1 |
| Miura, T | 1 |
| Wu, Y | 1 |
| Adi, D | 1 |
| Long, M | 1 |
| Wang, J | 1 |
| Liu, F | 1 |
| Gai, MT | 1 |
| Aierken, A | 1 |
| Li, MY | 1 |
| Li, Q | 1 |
| Wu, LQ | 1 |
| Ma, YT | 1 |
| Hujiaaihemaiti, M | 1 |
| Wang, JJ | 1 |
| Zuo, XR | 1 |
| Xu, J | 1 |
| Zhou, JY | 1 |
| Kong, H | 1 |
| Zeng, XN | 1 |
| Xie, WP | 1 |
| Cao, Q | 1 |
| Sobolewski, A | 1 |
| Rudarakanchana, N | 1 |
| Upton, PD | 1 |
| Yang, J | 1 |
| Crilley, TK | 1 |
| Trembath, RC | 1 |
| Morrell, NW | 1 |
| Dromparis, P | 1 |
| Paulin, R | 1 |
| Stenson, TH | 1 |
| Haromy, A | 1 |
| Sutendra, G | 1 |
| Michelakis, ED | 1 |
6 other studies available for 4-phenylbutyric acid and Hypertension, Pulmonary
| Article | Year |
|---|---|
[Excessive endoplasmic reticulum stress mediates brain damage in hypoxia hypercapnia induced pulmonary hypertension rats].
Topics: Animals; Apoptosis; Brain; Brain Injuries; Caspase 12; Caspase 3; Endoplasmic Reticulum Stress; Heat | 2017 |
Reduction of endoplasmic reticulum stress by 4-phenylbutyric acid prevents the development of hypoxia-induced pulmonary arterial hypertension.
Topics: Animals; Blood Pressure; Cells, Cultured; Cytokines; DNA-Binding Proteins; Endoplasmic Reticulum Cha | 2014 |
4-Phenylbutyric Acid Induces Protection against Pulmonary Arterial Hypertension in Rats.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Disease Models, Animal; eIF-2 Kinase; Endoplasmic | 2016 |
Evaluation and Treatment of Endoplasmic Reticulum (ER) Stress in Right Ventricular Dysfunction during Monocrotaline-Induced Rat Pulmonary Arterial Hypertension.
Topics: Activating Transcription Factor 6; Animals; Apoptosis; eIF-2 Kinase; Endoplasmic Reticulum Stress; H | 2016 |
Failure of bone morphogenetic protein receptor trafficking in pulmonary arterial hypertension: potential for rescue.
Topics: Amino Acid Substitution; Biological Transport, Active; Bone Morphogenetic Protein Receptors, Type I; | 2008 |
Attenuating endoplasmic reticulum stress as a novel therapeutic strategy in pulmonary hypertension.
Topics: Activating Transcription Factor 6; Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Ch | 2013 |