4-phenylbutyric acid has been researched along with Hyperoxaluria in 3 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Hyperoxaluria: Excretion of an excessive amount of OXALATES in the urine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hyperoxaluria is characterized by an increased excretion of urinary oxalate which is caused by inherited disorders or high oxalate intake leading to renal stone ailment." | 5.51 | Amelioration of hyperoxaluria-induced kidney dysfunction by chemical chaperone 4-phenylbutyric acid. ( Bhardwaj, R; Kaur, T; Randhawa, R, 2019) |
| "Hyperoxaluria-induced calcium oxalate crystallisation is associated with the generation of reactive oxygen species (ROS) via mitochondria and NADPH oxidase." | 3.85 | Effect of endoplasmic reticulum stress inhibition on hyperoxaluria-induced oxidative stress: influence on cellular ROS sources. ( Bhardwaj, R; Dhawan, DK; Kaur, T; Tandon, C, 2017) |
| "Hyperoxaluria is characterized by an increased excretion of urinary oxalate which is caused by inherited disorders or high oxalate intake leading to renal stone ailment." | 1.51 | Amelioration of hyperoxaluria-induced kidney dysfunction by chemical chaperone 4-phenylbutyric acid. ( Bhardwaj, R; Kaur, T; Randhawa, R, 2019) |
| "Hyperoxaluria-associated deposition of calcium oxalate crystals results from oxalate-induced renal injury and inflammation." | 1.51 | Modulatory effect of 4-phenyl butyric acid on hyperoxaluria-induced renal injury and inflammation. ( Naura, AS; Sharma, M; Singla, SK, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bhardwaj, R | 2 |
| Tandon, C | 1 |
| Dhawan, DK | 1 |
| Kaur, T | 2 |
| Randhawa, R | 1 |
| Sharma, M | 1 |
| Naura, AS | 1 |
| Singla, SK | 1 |
3 other studies available for 4-phenylbutyric acid and Hyperoxaluria
| Article | Year |
|---|---|
Effect of endoplasmic reticulum stress inhibition on hyperoxaluria-induced oxidative stress: influence on cellular ROS sources.
Topics: Animals; Antioxidants; Calcium Oxalate; Crystallization; Endoplasmic Reticulum Stress; Hyperoxaluria | 2017 |
Amelioration of hyperoxaluria-induced kidney dysfunction by chemical chaperone 4-phenylbutyric acid.
Topics: Animals; Biomarkers; Calcium Oxalate; Disease Models, Animal; Drug Evaluation, Preclinical; Endoplas | 2019 |
Modulatory effect of 4-phenyl butyric acid on hyperoxaluria-induced renal injury and inflammation.
Topics: Animals; Antineoplastic Agents; Biomarkers; Hyperoxaluria; Inflammation; Kidney Diseases; Male; Oxid | 2019 |