4-phenylbutyric acid has been researched along with Hypercholesterolemia in 2 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Hypercholesterolemia: A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cai, Z | 1 |
| Li, F | 1 |
| Gong, W | 1 |
| Liu, W | 1 |
| Duan, Q | 1 |
| Chen, C | 1 |
| Ni, L | 1 |
| Xia, Y | 1 |
| Cianflone, K | 1 |
| Dong, N | 1 |
| Wang, DW | 1 |
| FREDRICKSON, DS | 1 |
| STEINBERG, D | 1 |
2 other studies available for 4-phenylbutyric acid and Hypercholesterolemia
| Article | Year |
|---|---|
Endoplasmic reticulum stress participates in aortic valve calcification in hypercholesterolemic animals.
Topics: Aged; Animals; Aortic Valve; Aortic Valve Stenosis; Apolipoproteins E; Calcinosis; Calcium; Cell Dif | 2013 |
Failure of alpha-phenylbutyrate and beta-phenylvalerate in treatment of hypercholesterolemia.
Topics: Butyrates; Cholesterol; Humans; Hypercholesterolemia; Phenylbutyrates; Valerates | 1957 |