4-phenylbutyric acid has been researched along with Hemoglobinopathies in 2 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Hemoglobinopathies: A group of inherited disorders characterized by structural alterations within the hemoglobin molecule.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Okhovat, MA | 1 |
| Ziari, K | 1 |
| Ranjbaran, R | 1 |
| Nikouyan, N | 1 |
| Dover, GJ | 1 |
| Brusilow, S | 1 |
| Samid, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Sickle Cell Disease (SCD) Biochip': Towards a Simple and Reliable Way to Monitor Sickle Cell Disease[NCT02824471] | 100 participants (Anticipated) | Observational | 2014-10-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 other studies available for 4-phenylbutyric acid and Hemoglobinopathies
| Article | Year |
|---|---|
The effect of histone deacetylase inhibitors on AHSP expression.
Topics: Blood Proteins; Gene Expression Regulation; Hemoglobinopathies; Histone Deacetylase Inhibitors; Huma | 2018 |
Increased fetal hemoglobin in patients receiving sodium 4-phenylbutyrate.
Topics: Adult; Child; Child, Preschool; Female; Fetal Hemoglobin; Hemoglobinopathies; Humans; Male; Phenylbu | 1992 |