4-phenylbutyric acid has been researched along with Heart Failure in 1 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fu, HY | 1 |
| Sanada, S | 1 |
| Matsuzaki, T | 1 |
| Liao, Y | 1 |
| Okuda, K | 1 |
| Yamato, M | 1 |
| Tsuchida, S | 1 |
| Araki, R | 1 |
| Asano, Y | 1 |
| Asanuma, H | 1 |
| Asakura, M | 1 |
| French, BA | 1 |
| Sakata, Y | 1 |
| Kitakaze, M | 1 |
| Minamino, T | 1 |
1 other study available for 4-phenylbutyric acid and Heart Failure
| Article | Year |
|---|---|
Chemical Endoplasmic Reticulum Chaperone Alleviates Doxorubicin-Induced Cardiac Dysfunction.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Doxorubicin; Endoplasmic Reticulum; Endoplasmic Ret | 2016 |