4-phenylbutyric acid has been researched along with Glioblastoma in 7 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study we show that the chemical chaperone, glycerol, and the transcriptional regulator, sodium 4-phenylbutyrate, inhibit the constitutively activated inward current and reduce cell growth and migration in glioblastoma multiforme." | 7.73 | Surface expression of ASIC2 inhibits the amiloride-sensitive current and migration of glioma cells. ( Benos, DJ; Bubien, JK; Colby, G; Esimai, O; Fuller, CM; Gillespie, GY; Jovov, B; Kovacs, GG; Mapstone, TB; Markert, JM; Pahwa, AK; Vila-Carriles, WH; Zhou, ZH, 2006) |
| "We have investigated in vitro effects of anticancer therapy with the histone deacetylase inhibitor (HDACi) 4-phenylbutyrate (4-PB) combined with receptor tyrosine kinase inhibitors (RTKi) gefitinib or vandetanib on the survival of glioblastoma (U343MGa) and medulloblastoma (D324Med) cells." | 3.77 | Enhanced effects by 4-phenylbutyrate in combination with RTK inhibitors on proliferation in brain tumor cell models. ( Baryawno, N; Ekström, TJ; Johnsen, JI; Larsson, C; Marino, AM; Sofiadis, A; Vukojević, V, 2011) |
| " In this study we show that the chemical chaperone, glycerol, and the transcriptional regulator, sodium 4-phenylbutyrate, inhibit the constitutively activated inward current and reduce cell growth and migration in glioblastoma multiforme." | 3.73 | Surface expression of ASIC2 inhibits the amiloride-sensitive current and migration of glioma cells. ( Benos, DJ; Bubien, JK; Colby, G; Esimai, O; Fuller, CM; Gillespie, GY; Jovov, B; Kovacs, GG; Mapstone, TB; Markert, JM; Pahwa, AK; Vila-Carriles, WH; Zhou, ZH, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Romeo, MA | 1 |
| Gilardini Montani, MS | 1 |
| Benedetti, R | 1 |
| Garufi, A | 1 |
| D'Orazi, G | 1 |
| Cirone, M | 1 |
| Marino, AM | 1 |
| Sofiadis, A | 1 |
| Baryawno, N | 1 |
| Johnsen, JI | 1 |
| Larsson, C | 1 |
| Vukojević, V | 1 |
| Ekström, TJ | 3 |
| Asklund, T | 1 |
| Appelskog, IB | 2 |
| Ammerpohl, O | 2 |
| Almqvist, PM | 2 |
| Svechnikova, IG | 1 |
| Lui, WO | 1 |
| Vila-Carriles, WH | 1 |
| Kovacs, GG | 1 |
| Jovov, B | 1 |
| Zhou, ZH | 1 |
| Pahwa, AK | 1 |
| Colby, G | 1 |
| Esimai, O | 1 |
| Gillespie, GY | 1 |
| Mapstone, TB | 1 |
| Markert, JM | 1 |
| Fuller, CM | 1 |
| Bubien, JK | 1 |
| Benos, DJ | 1 |
| Lopez, CA | 1 |
| Feng, FY | 1 |
| Herman, JM | 1 |
| Nyati, MK | 1 |
| Lawrence, TS | 1 |
| Ljungman, M | 1 |
| Engelhard, HH | 1 |
| Homer, RJ | 1 |
| Duncan, HA | 1 |
| Rozental, J | 1 |
7 other studies available for 4-phenylbutyric acid and Glioblastoma
| Article | Year |
|---|---|
PBA Preferentially Impairs Cell Survival of Glioblastomas Carrying mutp53 by Reducing Its Expression Level, Stabilizing wtp53, Downregulating the Mevalonate Kinase and Dysregulating UPR.
Topics: Brain Neoplasms; Butyric Acid; Cell Line, Tumor; Cell Survival; Down-Regulation; Glioblastoma; Human | 2020 |
Enhanced effects by 4-phenylbutyrate in combination with RTK inhibitors on proliferation in brain tumor cell models.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line, Tumor; Cell Proliferatio | 2011 |
Histone deacetylase inhibitor 4-phenylbutyrate modulates glial fibrillary acidic protein and connexin 43 expression, and enhances gap-junction communication, in human glioblastoma cells.
Topics: Antineoplastic Agents; Blotting, Western; Cell Communication; Connexin 43; Gap Junctions; Glial Fibr | 2004 |
Histone deacetylase inhibitor 4-phenylbutyrate suppresses GAPDH mRNA expression in glioma cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Division; Down-Regulation; Enzyme I | 2004 |
Surface expression of ASIC2 inhibits the amiloride-sensitive current and migration of glioma cells.
Topics: Acid Sensing Ion Channels; Amiloride; Antineoplastic Agents; Brain Neoplasms; Cell Membrane; Cell Mo | 2006 |
Phenylbutyrate sensitizes human glioblastoma cells lacking wild-type p53 function to ionizing radiation.
Topics: Acetylation; Cell Line, Tumor; Cell Proliferation; G1 Phase; Glioblastoma; Histone Deacetylase Inhib | 2007 |
Inhibitory effects of phenylbutyrate on the proliferation, morphology, migration and invasiveness of malignant glioma cells.
Topics: Apoptosis; Cell Cycle; Cell Division; Cell Movement; Glioblastoma; Humans; Neoplasm Invasiveness; Ph | 1998 |