4-phenylbutyric acid has been researched along with Chronic Primary Open Angle Glaucoma in 4 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 2 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Maddineni, P | 1 |
| Kasetti, RB | 1 |
| Kodati, B | 1 |
| Yacoub, S | 1 |
| Zode, GS | 3 |
| Yan, X | 1 |
| Wu, S | 1 |
| Liu, Q | 1 |
| Li, Y | 1 |
| Zhu, W | 1 |
| Zhang, J | 1 |
| Sharma, AB | 1 |
| Lin, X | 1 |
| Searby, CC | 1 |
| Bugge, K | 1 |
| Kim, GH | 1 |
| Clark, AF | 1 |
| Sheffield, VC | 2 |
| Bugge, KE | 1 |
| Mohan, K | 1 |
| Grozdanic, SD | 1 |
| Peters, JC | 1 |
| Koehn, DR | 1 |
| Anderson, MG | 1 |
| Kardon, RH | 1 |
| Stone, EM | 1 |
4 other studies available for 4-phenylbutyric acid and Chronic Primary Open Angle Glaucoma
| Article | Year |
|---|---|
Sodium 4-Phenylbutyrate Reduces Ocular Hypertension by Degrading Extracellular Matrix Deposition via Activation of MMP9.
Topics: Animals; Aqueous Humor; Cornea; Endoplasmic Reticulum Stress; Enzyme Activation; Extracellular Matri | 2021 |
Accumulation of Asn450Tyr mutant myocilin in ER promotes apoptosis of human trabecular meshwork cells.
Topics: Apoptosis; Aqueous Humor; Calreticulin; Cell Survival; Cytoskeletal Proteins; Endoplasmic Reticulum; | 2020 |
Ocular-specific ER stress reduction rescues glaucoma in murine glucocorticoid-induced glaucoma.
Topics: Animals; Antineoplastic Agents; Dexamethasone; Disease Models, Animal; Endoplasmic Reticulum Stress; | 2014 |
Topical ocular sodium 4-phenylbutyrate rescues glaucoma in a myocilin mouse model of primary open-angle glaucoma.
Topics: Administration, Ophthalmic; Animals; Anti-Bacterial Agents; Aqueous Humor; Cytoskeletal Proteins; Di | 2012 |