4-phenylbutyric acid has been researched along with Genetic Predisposition in 2 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Malatack, JJ | 1 |
| Doyle, D | 1 |
| Yokoi, N | 1 |
| Fukata, Y | 1 |
| Kase, D | 1 |
| Miyazaki, T | 1 |
| Jaegle, M | 1 |
| Ohkawa, T | 1 |
| Takahashi, N | 1 |
| Iwanari, H | 1 |
| Mochizuki, Y | 1 |
| Hamakubo, T | 1 |
| Imoto, K | 1 |
| Meijer, D | 1 |
| Watanabe, M | 1 |
| Fukata, M | 1 |
1 review available for 4-phenylbutyric acid and Genetic Predisposition
| Article | Year |
|---|---|
A Drug Regimen for Progressive Familial Cholestasis Type 2.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 11; Benzothiepins; Biological Transport; Carba | 2018 |
1 other study available for 4-phenylbutyric acid and Genetic Predisposition
| Article | Year |
|---|---|
Chemical corrector treatment ameliorates increased seizure susceptibility in a mouse model of familial epilepsy.
Topics: ADAM Proteins; Animals; Disease Models, Animal; Epilepsy, Frontal Lobe; Genetic Predisposition to Di | 2015 |