4-phenylbutyric acid has been researched along with Genetic Diseases in 1 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The therapeutic potency of 4PB in these patients was tested by oral administration of this drug with gradually increasing dosage (200, 350, and 500 mg/kg/day) for 6 months." | 1.40 | Intractable itch relieved by 4-phenylbutyrate therapy in patients with progressive familial intrahepatic cholestasis type 1. ( Bessho, K; Hanada, K; Hasegawa, Y; Hayashi, H; Igarashi, K; Kimura, T; Kondou, H; Konishi, A; Kusuhara, H; Miyoshi, Y; Nagasaka, H; Nakao, K; Naoi, S; Ozono, K, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hasegawa, Y | 1 |
| Hayashi, H | 1 |
| Naoi, S | 1 |
| Kondou, H | 1 |
| Bessho, K | 1 |
| Igarashi, K | 1 |
| Hanada, K | 1 |
| Nakao, K | 1 |
| Kimura, T | 1 |
| Konishi, A | 1 |
| Nagasaka, H | 1 |
| Miyoshi, Y | 1 |
| Ozono, K | 1 |
| Kusuhara, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phenylbutyrate for Monogenetic Developmental and Epileptic Encephalopathy[NCT04937062] | Early Phase 1 | 50 participants (Anticipated) | Interventional | 2021-03-01 | Enrolling by invitation | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 other study available for 4-phenylbutyric acid and Genetic Diseases
| Article | Year |
|---|---|
Intractable itch relieved by 4-phenylbutyrate therapy in patients with progressive familial intrahepatic cholestasis type 1.
Topics: Administration, Oral; Adolescent; Child; Child, Preschool; Cholestasis, Intrahepatic; Disease Progre | 2014 |