4-phenylbutyric acid has been researched along with Gastrointestinal Stromal Tumors in 1 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Gastrointestinal Stromal Tumors: All tumors in the GASTROINTESTINAL TRACT arising from mesenchymal cells (MESODERM) except those of smooth muscle cells (LEIOMYOMA) or Schwann cells (SCHWANNOMA).
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Isosaka, M | 1 |
| Niinuma, T | 1 |
| Nojima, M | 1 |
| Kai, M | 1 |
| Yamamoto, E | 1 |
| Maruyama, R | 1 |
| Nobuoka, T | 1 |
| Nishida, T | 1 |
| Kanda, T | 1 |
| Taguchi, T | 1 |
| Hasegawa, T | 1 |
| Tokino, T | 1 |
| Hirata, K | 1 |
| Suzuki, H | 1 |
| Shinomura, Y | 1 |
1 other study available for 4-phenylbutyric acid and Gastrointestinal Stromal Tumors
| Article | Year |
|---|---|
A Screen for Epigenetically Silenced microRNA Genes in Gastrointestinal Stromal Tumors.
Topics: Azacitidine; Cell Line, Tumor; Cell Proliferation; CpG Islands; Decitabine; Gastrointestinal Neoplas | 2015 |