4-phenylbutyric acid has been researched along with Fatty Liver in 5 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Fatty Liver: Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of this study was to investigate the intervention effects of an endoplasmic reticulum stress (ERS) inhibitor 4-phenylbutyric acid (PBA) on liver steatosis induced by high-fructose feeding in rats and the possible underlying mechanisms." | 3.79 | The chemical chaperon 4-phenylbutyric acid ameliorates hepatic steatosis through inhibition of de novo lipogenesis in high-fructose-fed rats. ( Chen, SC; Hu, ZJ; Li, F; Peng, L; Ren, LP; Song, GY; Sun, W; Wei, L; Zhang, M, 2013) |
| "Fenofibrate treatment preserved AdipoR2 and phosphorylated AMPK (pAMPK) levels in palmitate-treated cells accompanied by reduced triglyceride (TG) accumulation and less activation of ER stress markers CCAAT/enhancer binding (C/EBPbeta) and eukaryotic translation initiation factor 2 alpha." | 1.35 | Fenofibrate and PBA prevent fatty acid-induced loss of adiponectin receptor and pAMPK in human hepatoma cells and in hepatitis C virus-induced steatosis. ( Friedman, JE; Janssen, RC; Qadri, I; Rahman, SM, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ren, LP | 1 |
| Song, GY | 1 |
| Hu, ZJ | 1 |
| Zhang, M | 1 |
| Peng, L | 1 |
| Chen, SC | 1 |
| Wei, L | 1 |
| Li, F | 1 |
| Sun, W | 1 |
| Zheng, J | 1 |
| Peng, C | 1 |
| Ai, Y | 1 |
| Wang, H | 1 |
| Xiao, X | 1 |
| Li, J | 1 |
| Rahman, SM | 1 |
| Qadri, I | 1 |
| Janssen, RC | 1 |
| Friedman, JE | 1 |
| Ben Mosbah, I | 1 |
| Alfany-Fernández, I | 1 |
| Martel, C | 1 |
| Zaouali, MA | 1 |
| Bintanel-Morcillo, M | 1 |
| Rimola, A | 1 |
| Rodés, J | 1 |
| Brenner, C | 1 |
| Roselló-Catafau, J | 1 |
| Peralta, C | 1 |
| Henkel, AS | 1 |
| Dewey, AM | 1 |
| Anderson, KA | 1 |
| Olivares, S | 1 |
| Green, RM | 1 |
5 other studies available for 4-phenylbutyric acid and Fatty Liver
| Article | Year |
|---|---|
The chemical chaperon 4-phenylbutyric acid ameliorates hepatic steatosis through inhibition of de novo lipogenesis in high-fructose-fed rats.
Topics: Animals; Blotting, Western; Fatty Liver; Fructose; In Situ Nick-End Labeling; Lipogenesis; Male; Phe | 2013 |
Docosahexaenoic Acid Ameliorates Fructose-Induced Hepatic Steatosis Involving ER Stress Response in Primary Mouse Hepatocytes.
Topics: Acetyl-CoA Carboxylase; Animals; Carnitine O-Palmitoyltransferase; Docosahexaenoic Acids; Endoplasmi | 2016 |
Fenofibrate and PBA prevent fatty acid-induced loss of adiponectin receptor and pAMPK in human hepatoma cells and in hepatitis C virus-induced steatosis.
Topics: AMP-Activated Protein Kinases; Blotting, Western; Carcinoma, Hepatocellular; CCAAT-Enhancer-Binding | 2009 |
Endoplasmic reticulum stress inhibition protects steatotic and non-steatotic livers in partial hepatectomy under ischemia-reperfusion.
Topics: Activating Transcription Factor 6; Animals; Caspase 12; Cytochromes c; Endoplasmic Reticulum; Fatty | 2010 |
Reducing endoplasmic reticulum stress does not improve steatohepatitis in mice fed a methionine- and choline-deficient diet.
Topics: Animals; Blood Glucose; Blotting, Western; Body Weight; Cholesterol; Choline Deficiency; Diet; Endop | 2012 |