4-phenylbutyric acid has been researched along with Eye Diseases, Hereditary in 3 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Eye Diseases, Hereditary: Transmission of gene defects or chromosomal aberrations/abnormalities which are expressed in extreme variation in the structure or function of the eye. These may be evident at birth, but may be manifested later with progression of the disorder.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, J | 1 |
| Taylor, RL | 1 |
| Baines, RA | 2 |
| Swanton, L | 1 |
| Freeman, S | 1 |
| Corneo, B | 1 |
| Patel, A | 1 |
| Marmorstein, A | 1 |
| Knudsen, T | 1 |
| Black, GC | 1 |
| Manson, F | 1 |
| Milenkovic, A | 1 |
| Milenkovic, VM | 1 |
| Wetzel, CH | 1 |
| Weber, BHF | 1 |
| Uggenti, C | 1 |
| Briant, K | 1 |
| Streit, AK | 1 |
| Thomson, S | 1 |
| Koay, YH | 1 |
| Swanton, E | 1 |
| Manson, FD | 1 |
3 other studies available for 4-phenylbutyric acid and Eye Diseases, Hereditary
| Article | Year |
|---|---|
Small Molecules Restore Bestrophin 1 Expression and Function of Both Dominant and Recessive Bestrophinopathies in Patient-Derived Retinal Pigment Epithelium.
Topics: Antineoplastic Agents; Bestrophins; Blotting, Western; Cell Membrane; Chloride Channels; Cycloheximi | 2020 |
BEST1 protein stability and degradation pathways differ between autosomal dominant Best disease and autosomal recessive bestrophinopathy accounting for the distinct retinal phenotypes.
Topics: Algorithms; Animals; Bestrophins; Cell Line; Dogs; Endoplasmic Reticulum; Eye Diseases, Hereditary; | 2018 |
Restoration of mutant bestrophin-1 expression, localisation and function in a polarised epithelial cell model.
Topics: Animals; Bestrophins; Biotinylation; Cell Polarity; Dogs; Endoplasmic Reticulum; Epithelial Cells; E | 2016 |