4-phenylbutyric acid has been researched along with Experimental Neoplasms in 3 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cachexia is a devastating syndrome that causes morbidity and mortality in a large number of patients with cancer." | 1.43 | Inhibition of ER stress and unfolding protein response pathways causes skeletal muscle wasting during cancer cachexia. ( Bohnert, KR; Gallot, YS; Hindi, SM; Kumar, A; Sato, S; Xiong, G, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, SY | 1 |
| Hong, EH | 2 |
| Jeong, JY | 1 |
| Cho, J | 1 |
| Seo, JH | 1 |
| Ko, HJ | 2 |
| Cho, HJ | 2 |
| Lee, BR | 1 |
| Chang, SY | 1 |
| Kwon, BE | 1 |
| Kim, HM | 1 |
| Kim, YJ | 1 |
| Lee, J | 1 |
| Cheon, JH | 1 |
| Bohnert, KR | 1 |
| Gallot, YS | 1 |
| Sato, S | 1 |
| Xiong, G | 1 |
| Hindi, SM | 1 |
| Kumar, A | 1 |
3 other studies available for 4-phenylbutyric acid and Experimental Neoplasms
| Article | Year |
|---|---|
Esterase-sensitive cleavable histone deacetylase inhibitor-coupled hyaluronic acid nanoparticles for boosting anticancer activities against lung adenocarcinoma.
Topics: A549 Cells; Adenocarcinoma of Lung; Animals; Apoptosis; Esterases; Female; Histone Deacetylase Inhib | 2019 |
Elevated endoplasmic reticulum stress reinforced immunosuppression in the tumor microenvironment via myeloid-derived suppressor cells.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Endoplasmic Reticulum Stress; H | 2014 |
Inhibition of ER stress and unfolding protein response pathways causes skeletal muscle wasting during cancer cachexia.
Topics: Activating Transcription Factor 6; Adenomatous Polyposis Coli Protein; AMP-Activated Protein Kinases | 2016 |