4-phenylbutyric acid has been researched along with Experimental Hepatoma in 1 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Svechnikova, I | 1 |
| Gray, SG | 1 |
| Kundrotiene, J | 1 |
| Ponthan, F | 1 |
| Kogner, P | 1 |
| Ekström, TJ | 1 |
1 other study available for 4-phenylbutyric acid and Experimental Hepatoma
| Article | Year |
|---|---|
Apoptosis and tumor remission in liver tumor xenografts by 4-phenylbutyrate.
Topics: Acetylation; alpha-Fetoproteins; Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellula | 2003 |