4-phenylbutyric acid has been researched along with Essential Hypertension in 1 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Essential Hypertension: Hypertension that occurs without known cause, or preexisting renal disease. Associated polymorphisms for a number of genes have been identified, including AGT, GNB3, and ECE1. OMIM: 145500
| Excerpt | Relevance | Reference |
|---|---|---|
| "Essential hypertension is the leading cause of premature death worldwide." | 1.51 | Endoplasmic reticulum stress inhibition blunts the development of essential hypertension in the spontaneously hypertensive rat. ( Carlisle, RE; Dickhout, JG; Lu, C; Naiel, S; Tat, V, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Naiel, S | 1 |
| Carlisle, RE | 1 |
| Lu, C | 1 |
| Tat, V | 1 |
| Dickhout, JG | 1 |
1 other study available for 4-phenylbutyric acid and Essential Hypertension
| Article | Year |
|---|---|
Endoplasmic reticulum stress inhibition blunts the development of essential hypertension in the spontaneously hypertensive rat.
Topics: Animals; Antihypertensive Agents; Biomarkers; Blood Pressure; Disease Models, Animal; Endoplasmic Re | 2019 |