4-phenylbutyric acid has been researched along with Enlarged Spleen in 1 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Singer, ST | 1 |
| Kuypers, FA | 1 |
| Olivieri, NF | 1 |
| Weatherall, DJ | 1 |
| Mignacca, R | 1 |
| Coates, TD | 1 |
| Davies, S | 1 |
| Sweeters, N | 1 |
| Vichinsky, EP | 1 |
1 trial available for 4-phenylbutyric acid and Enlarged Spleen
| Article | Year |
|---|---|
Single and combination drug therapy for fetal hemoglobin augmentation in hemoglobin E-beta 0-thalassemia: Considerations for treatment.
Topics: beta-Thalassemia; Blood Transfusion; Combined Modality Therapy; Drug Therapy, Combination; Erythropo | 2005 |