4-phenylbutyric acid has been researched along with Emphysema in 2 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Emphysema: A pathological accumulation of air in tissues or organs.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Emphysema is thought to be caused by the lack of circulating alpha1-AT to inhibit neutrophil elastase in the lung." | 1.31 | Chemical chaperones mediate increased secretion of mutant alpha 1-antitrypsin (alpha 1-AT) Z: A potential pharmacological strategy for prevention of liver injury and emphysema in alpha 1-AT deficiency. ( Burrows, JA; Perlmutter, DH; Willis, LK, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Burrows, JA | 1 |
| Willis, LK | 1 |
| Perlmutter, DH | 1 |
| Primhak, RA | 1 |
| Tanner, MS | 1 |
1 review available for 4-phenylbutyric acid and Emphysema
| Article | Year |
|---|---|
Alpha-1 antitrypsin deficiency.
Topics: Adult; alpha 1-Antitrypsin; alpha 1-Antitrypsin Deficiency; Animals; Antineoplastic Agents; Breast F | 2001 |
1 other study available for 4-phenylbutyric acid and Emphysema
| Article | Year |
|---|---|
Chemical chaperones mediate increased secretion of mutant alpha 1-antitrypsin (alpha 1-AT) Z: A potential pharmacological strategy for prevention of liver injury and emphysema in alpha 1-AT deficiency.
Topics: Administration, Oral; alpha 1-Antitrypsin; alpha 1-Antitrypsin Deficiency; Animals; Cell Line; Emphy | 2000 |