4-phenylbutyric acid has been researched along with Disease in 1 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Disease: A definite pathologic process with a characteristic set of signs and symptoms. It may affect the whole body or any of its parts, and its etiology, pathology, and prognosis may be known or unknown.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, S | 1 |
| Izumi, T | 1 |
| Hu, J | 1 |
| Jin, HH | 1 |
| Siddiqui, AA | 1 |
| Jacobson, SG | 1 |
| Bok, D | 1 |
| Jin, M | 1 |
1 other study available for 4-phenylbutyric acid and Disease
| Article | Year |
|---|---|
Rescue of enzymatic function for disease-associated RPE65 proteins containing various missense mutations in non-active sites.
Topics: Animals; Catalytic Domain; Cell Membrane; cis-trans-Isomerases; Disease; Gene Expression Regulation, | 2014 |