4-phenylbutyric acid has been researched along with Disease Models, Animal in 73 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here we examine the effects of valproic acid (VA) plus 4-phenylbutyric acid (4-PBA) on abnormal electrical brain activity, ER stress and apoptosis in acute seizures induced by pentylenetetrazole (PTZ)." | 8.12 | 4-Phenylbutyric Acid Plus Valproic Acid Exhibits the Therapeutic and Neuroprotective Effects in Acute Seizures Induced by Pentylenetetrazole. ( Amanvermez, R; Arslan, G; Gün, S; Rzayev, E; Tiryaki, ES, 2022) |
| "The present study aimed to determine whether intestinal epithelial cell (IECs) apoptosis could be induced by endoplasmic reticulum stress (ERS) in severe acute pancreatitis (SAP), and the role of chemical chaperone 4-phenylbutyric acid (4-PBA) in SAP-associated intestinal barrier injury." | 7.91 | 4-Phenylbutyric Acid Attenuates Endoplasmic Reticulum Stress-Mediated Intestinal Epithelial Cell Apoptosis in Rats with Severe Acute Pancreatitis. ( Deng, WH; Guo, WY; Hong, YP; Mei, FC; Wang, WX; Xu, S; You, YD; Yu, J; Zhao, L; Zhou, Y, 2019) |
| "Lewisite is a potent arsenic-based chemical warfare agent known to induce painful cutaneous inflammation and blistering." | 7.83 | Molecular Mechanism Underlying Pathogenesis of Lewisite-Induced Cutaneous Blistering and Inflammation: Chemical Chaperones as Potential Novel Antidotes. ( Afaq, F; Agarwal, A; Athar, M; Croutch, CR; Elmets, CA; Li, C; Srivastava, RK; Weng, Z, 2016) |
| "Hyperoxaluria is characterized by an increased excretion of urinary oxalate which is caused by inherited disorders or high oxalate intake leading to renal stone ailment." | 5.51 | Amelioration of hyperoxaluria-induced kidney dysfunction by chemical chaperone 4-phenylbutyric acid. ( Bhardwaj, R; Kaur, T; Randhawa, R, 2019) |
| " Here we examine the effects of valproic acid (VA) plus 4-phenylbutyric acid (4-PBA) on abnormal electrical brain activity, ER stress and apoptosis in acute seizures induced by pentylenetetrazole (PTZ)." | 4.12 | 4-Phenylbutyric Acid Plus Valproic Acid Exhibits the Therapeutic and Neuroprotective Effects in Acute Seizures Induced by Pentylenetetrazole. ( Amanvermez, R; Arslan, G; Gün, S; Rzayev, E; Tiryaki, ES, 2022) |
| "The present study aimed to determine whether intestinal epithelial cell (IECs) apoptosis could be induced by endoplasmic reticulum stress (ERS) in severe acute pancreatitis (SAP), and the role of chemical chaperone 4-phenylbutyric acid (4-PBA) in SAP-associated intestinal barrier injury." | 3.91 | 4-Phenylbutyric Acid Attenuates Endoplasmic Reticulum Stress-Mediated Intestinal Epithelial Cell Apoptosis in Rats with Severe Acute Pancreatitis. ( Deng, WH; Guo, WY; Hong, YP; Mei, FC; Wang, WX; Xu, S; You, YD; Yu, J; Zhao, L; Zhou, Y, 2019) |
| " In this study, we investigated the expression of key molecules in the ER stress pathways following nonarteritic anterior ischemic optic neuropathy (AION), the most common acute optic neuropathy in adults over 50, and assessed the impact of chemical chaperon 4-phenylbutyric acid (4-PBA) in vivo." | 3.91 | Increased ER Stress After Experimental Ischemic Optic Neuropathy and Improved RGC and Oligodendrocyte Survival After Treatment With Chemical Chaperon. ( Heng, K; Hu, Y; Huang, H; Kumar, V; Liao, YJ; Mesentier-Louro, LA; Oh, AJ; Shariati, MA, 2019) |
| " Anticonvulsant activity was tested against clonic seizures induced by pentylenetetrazole (PTZ, 60 mg/kg, i." | 3.85 | In silico Screening and Evaluation of the Anticonvulsant Activity of Docosahexaenoic Acid-Like Molecules in Experimental Models of Seizures. ( Gharibi Loron, A; Narenjkar, J; Sardari, S; Sayyah, M, 2017) |
| " By using the streptomycin-treated mouse model, we found that Taconic mice treated with PBA exhibited significantly lower S Typhimurium intestinal colonization and dissemination to the reticuloendothelial system, as well as lower levels of inflammation." | 3.83 | Beneficial Effects of Sodium Phenylbutyrate Administration during Infection with Salmonella enterica Serovar Typhimurium. ( Behnsen, J; Edwards, RA; Gao, N; Jellbauer, S; Murphy, C; Nguyen, T; Perez Lopez, A; Raffatellu, M, 2016) |
| "Lewisite is a potent arsenic-based chemical warfare agent known to induce painful cutaneous inflammation and blistering." | 3.83 | Molecular Mechanism Underlying Pathogenesis of Lewisite-Induced Cutaneous Blistering and Inflammation: Chemical Chaperones as Potential Novel Antidotes. ( Afaq, F; Agarwal, A; Athar, M; Croutch, CR; Elmets, CA; Li, C; Srivastava, RK; Weng, Z, 2016) |
| " However, the main drawback to its therapeutic use is the high dosage required (up to 15 g/day)." | 2.47 | Defining the mechanism of action of 4-phenylbutyrate to develop a small-molecule-based therapy for Alzheimer's disease. ( Cuadrado-Tejedor, M; Franco, R; García-Osta, A; Oyarzabal, J; Ricobaraza, A, 2011) |
| "Proximal spinal muscular atrophy (SMA) is a leading genetic cause for infant death in the world and results from the selective loss of motor neurons in the spinal cord." | 1.91 | Evaluation of the orally bioavailable 4-phenylbutyrate-tethered trichostatin A analogue AR42 in models of spinal muscular atrophy. ( Burghes, AHM; Butchbach, MER; Connell, AJ; Harris, AW; Kirk, RW; Lumpkin, CJ; Pellizzoni, L; Saieva, L; Whiting, JA, 2023) |
| "5-Fluorouracil (5-FU)-induced oral mucositis has a severe negative impact on the patient's quality of life." | 1.72 | Protective effect of endoplasmic reticulum stress inhibition on 5-fluorouracil-induced oral mucositis. ( Cao, YN; Chen, C; Hou, Y; Li, M; Shan, E; Shan, J; Wang, J; Wang, Y; Zhang, L; Zhou, Y, 2022) |
| "Renal fibrosis is a potent predictor of progression in patients and is often accompanied by inflammation and oxidative stress; however, the mechanisms involved in these alterations are not well established." | 1.62 | Role of endoplasmic reticulum stress in renal damage after myocardial infarction. ( Cachofeiro, V; de la Fuente-Chávez, L; Delgado-Valero, B; Islas, F; Luaces, M; Martínez-Martínez, E; Ramchandani, B; Romero-Miranda, A; Visitación Bartolomé, M, 2021) |
| "Hyperoxaluria is characterized by an increased excretion of urinary oxalate which is caused by inherited disorders or high oxalate intake leading to renal stone ailment." | 1.51 | Amelioration of hyperoxaluria-induced kidney dysfunction by chemical chaperone 4-phenylbutyric acid. ( Bhardwaj, R; Kaur, T; Randhawa, R, 2019) |
| "Essential hypertension is the leading cause of premature death worldwide." | 1.51 | Endoplasmic reticulum stress inhibition blunts the development of essential hypertension in the spontaneously hypertensive rat. ( Carlisle, RE; Dickhout, JG; Lu, C; Naiel, S; Tat, V, 2019) |
| "Joint contracture is a common complication for people with joint immobility that involves fibrosis structural alteration in the joint capsule." | 1.48 | Endoplasmic reticulum stress-dependent ROS production mediates synovial myofibroblastic differentiation in the immobilization-induced rat knee joint contracture model. ( He, R; Jiang, S; Liang, T; Lu, Y; Ren, J; Wang, K; Wang, Z; Xiao, D; Yi, X; Zhu, L, 2018) |
| "Proteinuria is one of the primary risk factors for the progression of chronic kidney disease (CKD) and has been implicated in the induction of endoplasmic reticulum (ER) stress." | 1.46 | Endoplasmic reticulum stress inhibition limits the progression of chronic kidney disease in the Dahl salt-sensitive rat. ( Ask, K; Brimble, E; Carlisle, RE; Chahal, J; Dickhout, JG; Lu, C; Upagupta, C; Yum, V, 2017) |
| "To identify the cellular mechanism of lung inflammation during lipopolysaccharide (LPS)-induced mouse model of ALI, we investigated the influence of classic ER stress inhibitor 4-phenyl butyric acid (4-PBA) on ER stress and autophagy, which partially affect the activation of inflammation, both in LPS-induced ALI mouse model and human alveolar epithelial cell model." | 1.46 | 4-PBA inhibits LPS-induced inflammation through regulating ER stress and autophagy in acute lung injury models. ( Chen, R; Chen, S; Gong, Y; Kong, X; Li, Z; Liu, Y; Sang, W; Xue, F; Zeng, M; Zhang, H, 2017) |
| "Sepsis and septic shock are the common complications in ICUs." | 1.43 | 4-Phenylbutyric Acid Reveals Good Beneficial Effects on Vital Organ Function via Anti-Endoplasmic Reticulum Stress in Septic Rats. ( Chen, X; Lan, D; Li, T; Liu, L; Wu, H; Wu, Y; Yang, G; Zang, J; Zhu, Y, 2016) |
| "Human neurodegenerative tauopathies exhibit pathological tau aggregates in the brain along with diverse clinical features including cognitive and motor dysfunction." | 1.43 | Tauopathy induced by low level expression of a human brain-derived tau fragment in mice is rescued by phenylbutyrate. ( Bondulich, MK; Brion, JP; Guo, T; Hanger, DP; Hortobagyi, T; Manion, J; Meehan, C; Mitchell, JC; Noble, W; Rodriguez Martin, T; Stygelbout, V; Yankova, N, 2016) |
| "Methimazole (MMI) was applied to construct a noninvasive SCH mouse model." | 1.43 | Endoplasmic Reticulum Stress May Play a Pivotal Role in Lipid Metabolic Disorders in a Novel Mouse Model of Subclinical Hypothyroidism. ( Bo, T; Chen, W; Ding, S; Gao, L; Li, C; Li, Y; Liu, X; Wang, L; Wu, K; Xu, C; Zhao, J; Zhou, L, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (8.22) | 29.6817 |
| 2010's | 49 (67.12) | 24.3611 |
| 2020's | 18 (24.66) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, Q | 1 |
| Thompson, J | 1 |
| Hu, Y | 3 |
| Lesnefsky, EJ | 1 |
| Cao, YN | 1 |
| Wang, Y | 3 |
| Zhang, L | 1 |
| Hou, Y | 1 |
| Shan, J | 1 |
| Li, M | 1 |
| Chen, C | 2 |
| Zhou, Y | 2 |
| Shan, E | 1 |
| Wang, J | 3 |
| Xing, D | 1 |
| Zhou, Q | 1 |
| Xu, J | 1 |
| Huang, Y | 1 |
| Yuan, M | 1 |
| Duan, F | 1 |
| Yang, Y | 1 |
| Lou, B | 1 |
| Lin, X | 2 |
| Rzayev, E | 1 |
| Amanvermez, R | 1 |
| Gün, S | 1 |
| Tiryaki, ES | 1 |
| Arslan, G | 1 |
| Tiwari, S | 1 |
| Gupta, P | 1 |
| Singh, A | 1 |
| Chaturvedi, S | 1 |
| Wahajuddin, M | 1 |
| Mishra, A | 1 |
| Singh, S | 1 |
| Alfahel, L | 1 |
| Argueti-Ostrovsky, S | 1 |
| Barel, S | 1 |
| Ali Saleh, M | 1 |
| Kahn, J | 1 |
| Azoulay-Ginsburg, S | 2 |
| Rothstein, A | 1 |
| Ebbinghaus, S | 2 |
| Gruzman, A | 2 |
| Israelson, A | 1 |
| Baumanns, S | 1 |
| Muehlemeyer, F | 1 |
| Miesbauer, LC | 1 |
| Baake, J | 1 |
| Roloff, EM | 1 |
| Beis, DM | 1 |
| Wenzel, U | 1 |
| Lumpkin, CJ | 1 |
| Harris, AW | 1 |
| Connell, AJ | 1 |
| Kirk, RW | 1 |
| Whiting, JA | 1 |
| Saieva, L | 1 |
| Pellizzoni, L | 1 |
| Burghes, AHM | 1 |
| Butchbach, MER | 1 |
| Min, BK | 1 |
| Kang, HJ | 1 |
| Choi, BJ | 1 |
| Jeon, YH | 1 |
| Cho, JY | 1 |
| Lee, IK | 1 |
| Kim, DW | 1 |
| Powell, N | 1 |
| Pantazi, E | 1 |
| Pavlidis, P | 1 |
| Tsakmaki, A | 1 |
| Li, K | 1 |
| Yang, F | 1 |
| Parker, A | 1 |
| Pin, C | 1 |
| Cozzetto, D | 1 |
| Minns, D | 1 |
| Stolarczyk, E | 1 |
| Saveljeva, S | 1 |
| Mohamed, R | 1 |
| Lavender, P | 1 |
| Afzali, B | 1 |
| Digby-Bell, J | 1 |
| Tjir-Li, T | 1 |
| Kaser, A | 1 |
| Friedman, J | 1 |
| MacDonald, TT | 1 |
| Bewick, GA | 1 |
| Lord, GM | 1 |
| Shi, Z | 1 |
| Yin, Y | 1 |
| Li, C | 4 |
| Ding, H | 1 |
| Mu, N | 1 |
| Jin, S | 1 |
| Ma, H | 1 |
| Liu, M | 1 |
| Zhou, J | 1 |
| Klejbor, I | 1 |
| Mahmood, S | 1 |
| Melka, N | 1 |
| Ebertowska, A | 1 |
| Morys, J | 1 |
| Stachowiak, EK | 1 |
| Stachowiak, MK | 1 |
| Patel, MS | 1 |
| Delgado-Valero, B | 1 |
| de la Fuente-Chávez, L | 1 |
| Romero-Miranda, A | 1 |
| Visitación Bartolomé, M | 1 |
| Ramchandani, B | 1 |
| Islas, F | 1 |
| Luaces, M | 1 |
| Cachofeiro, V | 1 |
| Martínez-Martínez, E | 1 |
| Di Salvio, M | 1 |
| Weitman, M | 1 |
| Afri, M | 1 |
| Ribeiro, S | 1 |
| Cestra, G | 1 |
| Ryu, YK | 1 |
| Park, HY | 1 |
| Go, J | 1 |
| Choi, DH | 1 |
| Choi, YK | 1 |
| Rhee, M | 1 |
| Lee, CH | 1 |
| Kim, KS | 1 |
| de Pablo, S | 1 |
| Rodríguez-Comas, J | 1 |
| Díaz-Catalán, D | 1 |
| Alcarraz-Vizán, G | 1 |
| Castaño, C | 1 |
| Moreno-Vedia, J | 1 |
| Montane, J | 1 |
| Parrizas, M | 1 |
| Servitja, JM | 1 |
| Novials, A | 1 |
| He, J | 1 |
| Gong, M | 1 |
| Wang, Z | 2 |
| Liu, D | 1 |
| Xie, B | 1 |
| Luo, C | 1 |
| Li, G | 1 |
| Tse, G | 1 |
| Liu, T | 2 |
| Wiersma, M | 1 |
| Meijering, RAM | 1 |
| Qi, XY | 1 |
| Zhang, D | 1 |
| Hoogstra-Berends, F | 1 |
| Sibon, OCM | 1 |
| Henning, RH | 1 |
| Nattel, S | 1 |
| Brundel, BJJM | 1 |
| Jiang, S | 1 |
| He, R | 1 |
| Zhu, L | 1 |
| Liang, T | 1 |
| Lu, Y | 2 |
| Ren, J | 1 |
| Yi, X | 1 |
| Xiao, D | 1 |
| Wang, K | 1 |
| Randhawa, R | 1 |
| Bhardwaj, R | 1 |
| Kaur, T | 1 |
| You, YD | 1 |
| Deng, WH | 1 |
| Guo, WY | 1 |
| Zhao, L | 1 |
| Mei, FC | 1 |
| Hong, YP | 1 |
| Yu, J | 1 |
| Xu, S | 1 |
| Wang, WX | 1 |
| Bonnemaison, ML | 1 |
| Marks-Nelson, ES | 1 |
| Boesen, EI | 1 |
| Naiel, S | 1 |
| Carlisle, RE | 3 |
| Lu, C | 3 |
| Tat, V | 1 |
| Dickhout, JG | 3 |
| Kumar, V | 1 |
| Mesentier-Louro, LA | 1 |
| Oh, AJ | 1 |
| Heng, K | 1 |
| Shariati, MA | 1 |
| Huang, H | 1 |
| Liao, YJ | 1 |
| Spörrer, M | 1 |
| Prochnicki, A | 1 |
| Tölle, RC | 1 |
| Nyström, A | 1 |
| Esser, PR | 1 |
| Homberg, M | 1 |
| Athanasiou, I | 1 |
| Zingkou, E | 1 |
| Schilling, A | 1 |
| Gerum, R | 1 |
| Thievessen, I | 1 |
| Winter, L | 1 |
| Bruckner-Tuderman, L | 1 |
| Fabry, B | 1 |
| Magin, TM | 1 |
| Dengjel, J | 1 |
| Schröder, R | 1 |
| Kiritsi, D | 1 |
| Qiu, Y | 1 |
| Yao, J | 1 |
| Jia, L | 1 |
| Thompson, DA | 1 |
| Zacks, DN | 1 |
| Mariángelo, JIE | 1 |
| Román, B | 1 |
| Silvestri, MA | 1 |
| Salas, M | 1 |
| Vittone, L | 1 |
| Said, M | 1 |
| Mundiña-Weilenmann, C | 1 |
| Cuadrado-Tejedor, M | 4 |
| Ricobaraza, AL | 1 |
| Torrijo, R | 1 |
| Franco, R | 2 |
| Garcia-Osta, A | 4 |
| Tietz Bogert, PS | 1 |
| Huang, BQ | 1 |
| Gradilone, SA | 1 |
| Masyuk, TV | 1 |
| Moulder, GL | 1 |
| Ekker, SC | 1 |
| Larusso, NF | 1 |
| Spitler, KM | 1 |
| Matsumoto, T | 1 |
| Webb, RC | 1 |
| Cai, Z | 1 |
| Li, F | 1 |
| Gong, W | 1 |
| Liu, W | 1 |
| Duan, Q | 1 |
| Ni, L | 1 |
| Xia, Y | 1 |
| Cianflone, K | 1 |
| Dong, N | 1 |
| Wang, DW | 1 |
| Zhu, Y | 3 |
| Chen, YL | 1 |
| Ding, XY | 1 |
| Xu, GY | 1 |
| Hu, LL | 1 |
| Hou, FF | 1 |
| Zhou, QG | 1 |
| Kemter, E | 1 |
| Sklenak, S | 1 |
| Rathkolb, B | 1 |
| Hrabě de Angelis, M | 1 |
| Wolf, E | 1 |
| Aigner, B | 1 |
| Wanke, R | 1 |
| Zode, GS | 2 |
| Sharma, AB | 1 |
| Searby, CC | 1 |
| Bugge, K | 1 |
| Kim, GH | 1 |
| Clark, AF | 1 |
| Sheffield, VC | 2 |
| Yao, ZH | 1 |
| Kang, X | 1 |
| Yang, L | 1 |
| Niu, Y | 1 |
| Gong, CX | 1 |
| Tian, Q | 1 |
| Wang, JZ | 1 |
| Yamada, H | 1 |
| Nakajima, T | 1 |
| Domon, H | 1 |
| Honda, T | 1 |
| Yamazaki, K | 1 |
| Yokoi, N | 1 |
| Fukata, Y | 1 |
| Kase, D | 1 |
| Miyazaki, T | 1 |
| Jaegle, M | 1 |
| Ohkawa, T | 1 |
| Takahashi, N | 1 |
| Iwanari, H | 1 |
| Mochizuki, Y | 1 |
| Hamakubo, T | 1 |
| Imoto, K | 1 |
| Meijer, D | 1 |
| Watanabe, M | 1 |
| Fukata, M | 1 |
| Berthier, A | 1 |
| Payá, M | 1 |
| García-Cabrero, AM | 1 |
| Ballester, MI | 1 |
| Heredia, M | 1 |
| Serratosa, JM | 2 |
| Sánchez, MP | 2 |
| Sanz, P | 2 |
| Takayanagi, T | 1 |
| Kawai, T | 1 |
| Forrester, SJ | 1 |
| Obama, T | 1 |
| Tsuji, T | 1 |
| Fukuda, Y | 1 |
| Elliott, KJ | 1 |
| Tilley, DG | 1 |
| Davisson, RL | 1 |
| Park, JY | 1 |
| Eguchi, S | 1 |
| Luo, T | 1 |
| Chen, B | 1 |
| Wang, X | 2 |
| Fan, H | 1 |
| Tang, HB | 1 |
| Kang, J | 1 |
| Shan, L | 1 |
| Song, H | 1 |
| Zhu, K | 1 |
| Ju, G | 1 |
| Wang, YZ | 1 |
| Yang, G | 2 |
| Peng, X | 1 |
| Lan, D | 2 |
| Wu, Y | 3 |
| Li, T | 2 |
| Liu, L | 2 |
| Zhou, H | 1 |
| Zhu, J | 1 |
| Yue, S | 1 |
| Lu, L | 1 |
| Busuttil, RW | 1 |
| Kupiec-Weglinski, JW | 1 |
| Zhai, Y | 1 |
| Lee, HY | 1 |
| Marahatta, A | 1 |
| Bhandary, B | 1 |
| Kim, HR | 1 |
| Chae, HJ | 1 |
| Wu, H | 1 |
| Zang, J | 1 |
| Chen, X | 1 |
| Jain, K | 1 |
| Suryakumar, G | 1 |
| Ganju, L | 1 |
| Singh, SB | 1 |
| Sturm, E | 1 |
| Fellner, L | 1 |
| Krismer, F | 1 |
| Poewe, W | 1 |
| Wenning, GK | 1 |
| Stefanova, N | 1 |
| Bondulich, MK | 1 |
| Guo, T | 1 |
| Meehan, C | 1 |
| Manion, J | 1 |
| Rodriguez Martin, T | 1 |
| Mitchell, JC | 1 |
| Hortobagyi, T | 1 |
| Yankova, N | 1 |
| Stygelbout, V | 1 |
| Brion, JP | 1 |
| Noble, W | 1 |
| Hanger, DP | 1 |
| Adi, D | 1 |
| Long, M | 1 |
| Liu, F | 1 |
| Gai, MT | 1 |
| Aierken, A | 1 |
| Li, MY | 1 |
| Li, Q | 1 |
| Wu, LQ | 1 |
| Ma, YT | 1 |
| Hujiaaihemaiti, M | 1 |
| Jellbauer, S | 1 |
| Perez Lopez, A | 1 |
| Behnsen, J | 1 |
| Gao, N | 1 |
| Nguyen, T | 1 |
| Murphy, C | 1 |
| Edwards, RA | 1 |
| Raffatellu, M | 1 |
| Srivastava, RK | 1 |
| Weng, Z | 1 |
| Croutch, CR | 1 |
| Agarwal, A | 1 |
| Elmets, CA | 1 |
| Afaq, F | 1 |
| Athar, M | 1 |
| Zhou, L | 1 |
| Ding, S | 1 |
| Li, Y | 1 |
| Wang, L | 1 |
| Chen, W | 1 |
| Bo, T | 1 |
| Wu, K | 1 |
| Liu, X | 1 |
| Zhao, J | 1 |
| Xu, C | 1 |
| Gao, L | 1 |
| Gharibi Loron, A | 1 |
| Sardari, S | 1 |
| Narenjkar, J | 1 |
| Sayyah, M | 1 |
| Takatori, O | 1 |
| Usui, S | 1 |
| Okajima, M | 1 |
| Kaneko, S | 1 |
| Ootsuji, H | 1 |
| Takashima, SI | 1 |
| Kobayashi, D | 1 |
| Murai, H | 1 |
| Furusho, H | 1 |
| Takamura, M | 1 |
| Yum, V | 1 |
| Brimble, E | 1 |
| Chahal, J | 1 |
| Upagupta, C | 1 |
| Ask, K | 2 |
| Mohammed-Ali, Z | 1 |
| Marway, MK | 1 |
| Lukic, D | 1 |
| Krepinsky, JC | 1 |
| Mukai, S | 1 |
| Ogawa, Y | 1 |
| Urano, F | 1 |
| Kudo-Saito, C | 1 |
| Kawakami, Y | 1 |
| Tsubota, K | 1 |
| Sánchez-Elexpuru, G | 1 |
| Zeng, M | 1 |
| Sang, W | 1 |
| Chen, S | 1 |
| Chen, R | 1 |
| Zhang, H | 2 |
| Xue, F | 1 |
| Li, Z | 1 |
| Liu, Y | 1 |
| Gong, Y | 1 |
| Kong, X | 1 |
| Ricobaraza, A | 3 |
| Pérez-Mediavilla, A | 1 |
| Frechilla, D | 1 |
| Del Río, J | 1 |
| Xu, TY | 1 |
| Chen, RH | 1 |
| Wang, P | 1 |
| Zhang, RY | 1 |
| Ke, SF | 1 |
| Miao, CY | 1 |
| Marco, S | 1 |
| Pérez-Otaño, I | 1 |
| Oyarzabal, J | 1 |
| Bugge, KE | 1 |
| Mohan, K | 1 |
| Grozdanic, SD | 1 |
| Peters, JC | 1 |
| Koehn, DR | 1 |
| Anderson, MG | 1 |
| Kardon, RH | 1 |
| Stone, EM | 1 |
| Park, CS | 1 |
| Cha, H | 1 |
| Kwon, EJ | 1 |
| Sreenivasaiah, PK | 1 |
| Kim, DH | 1 |
| Dromparis, P | 1 |
| Paulin, R | 1 |
| Stenson, TH | 1 |
| Haromy, A | 1 |
| Sutendra, G | 1 |
| Michelakis, ED | 1 |
| Liang, B | 1 |
| Wang, S | 1 |
| Wang, Q | 1 |
| Zhang, W | 1 |
| Viollet, B | 1 |
| Zou, MH | 1 |
| Qi, X | 1 |
| Hosoi, T | 1 |
| Okuma, Y | 2 |
| Kaneko, M | 2 |
| Nomura, Y | 1 |
| Hao, CL | 1 |
| Lin, D | 1 |
| Wang, LH | 1 |
| Xing, HY | 1 |
| Wang, M | 1 |
| Wang, JX | 1 |
| Ozcan, U | 1 |
| Yilmaz, E | 1 |
| Ozcan, L | 1 |
| Furuhashi, M | 1 |
| Vaillancourt, E | 1 |
| Smith, RO | 1 |
| Görgün, CZ | 1 |
| Hotamisligil, GS | 1 |
| Inden, M | 1 |
| Kitamura, Y | 1 |
| Takeuchi, H | 1 |
| Yanagida, T | 1 |
| Takata, K | 1 |
| Kobayashi, Y | 1 |
| Taniguchi, T | 1 |
| Yoshimoto, K | 1 |
| Taira, T | 1 |
| Ariga, H | 1 |
| Shimohama, S | 1 |
| Mulhern, ML | 1 |
| Madson, CJ | 1 |
| Kador, PF | 1 |
| Randazzo, J | 1 |
| Shinohara, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Observer-Blinded, Placebo-Controlled, Multiple-Ascending, Dose-Escalation Study to Explore the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Repeat Intravenous Administrations of UTTR1147A in Healthy Volunteers and Patients With Ulcer[NCT02749630] | Phase 1 | 70 participants (Actual) | Interventional | 2016-04-11 | Completed | ||
| A Pharmacokinetic and Pharmacodynamic Study of AMX0035 in Patients With ALS[NCT04987671] | Phase 1/Phase 2 | 14 participants (Anticipated) | Interventional | 2021-08-05 | Active, not recruiting | ||
| Phenylbutyrate for Monogenetic Developmental and Epileptic Encephalopathy[NCT04937062] | Early Phase 1 | 50 participants (Anticipated) | Interventional | 2021-03-01 | Enrolling by invitation | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for 4-phenylbutyric acid and Disease Models, Animal
| Article | Year |
|---|---|
Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells.
Topics: Animals; Anti-Bacterial Agents; Apoptosis; Cell Survival; Chronic Disease; Colitis; Colon; Crohn Dis | 2020 |
Defining the mechanism of action of 4-phenylbutyrate to develop a small-molecule-based therapy for Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Humans; Phenylbutyrates | 2011 |
71 other studies available for 4-phenylbutyric acid and Disease Models, Animal
| Article | Year |
|---|---|
Reversing mitochondrial defects in aged hearts: role of mitochondrial calpain activation.
Topics: Age Factors; Animals; Calpain; Cysteine Proteinase Inhibitors; Dipeptides; Disease Models, Animal; E | 2022 |
Protective effect of endoplasmic reticulum stress inhibition on 5-fluorouracil-induced oral mucositis.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Endoplasmic Reticulum Stress; Fluorouracil; | 2022 |
Effects of Tauroursodeoxycholic Acid and 4-Phenylbutyric Acid on Selenium Distribution in Mice Model with Type 1 Diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Models, Animal; Endopla | 2023 |
Inhibition of endoplasmic reticulum stress by 4-phenylbutyrate alleviates retinal inflammation and the apoptosis of retinal ganglion cells after ocular alkali burn in mice.
Topics: Animals; Apoptosis; Burns, Chemical; Disease Models, Animal; Endoplasmic Reticulum Stress; Inflammat | 2022 |
4-Phenylbutyric Acid Plus Valproic Acid Exhibits the Therapeutic and Neuroprotective Effects in Acute Seizures Induced by Pentylenetetrazole.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Male; Neuroprotective Agents; Pentylenet | 2022 |
4-Phenylbutyrate Mitigates the Motor Impairment and Dopaminergic Neuronal Death During Parkinson's Disease Pathology via Targeting VDAC1 Mediated Mitochondrial Function and Astrocytes Activation.
Topics: alpha-Synuclein; Animals; Astrocytes; bcl-2-Associated X Protein; Calcium; Caspase 3; Cytochromes; D | 2022 |
4-Phenylbutyric Acid (4-PBA) Derivatives Prevent SOD1 Amyloid Aggregation In Vitro with No Effect on Disease Progression in SOD1-ALS Mice.
Topics: Amyloid; Amyloidogenic Proteins; Amyotrophic Lateral Sclerosis; Animals; Butylamines; Disease Models | 2022 |
4-Phenylbutyric acid attenuates amyloid-β proteotoxicity through activation of HSF-1 in an Alzheimer's disease model of the nematode Caenorhabditiselegans.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Caenorhabditis elegans; Caenorhabditis elegans Pr | 2023 |
Evaluation of the orally bioavailable 4-phenylbutyrate-tethered trichostatin A analogue AR42 in models of spinal muscular atrophy.
Topics: Animals; Disease Models, Animal; Histone Deacetylase Inhibitors; Mice; Motor Neurons; Muscular Atrop | 2023 |
Phenylbutyrate Ameliorates High-Fat Diet-Induced Obesity via Brown Adipose Tissue Activation.
Topics: Adipocytes; Adipose Tissue, Brown; Animals; Anti-Obesity Agents; Diet, High-Fat; Disease Models, Ani | 2019 |
Lipocalin-2-induced proliferative endoplasmic reticulum stress participates in Kawasaki disease-related pulmonary arterial abnormalities.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Endoplasmic Reticulum Stress; Lipocalin-2; M | 2021 |
Phenylbutyrate administration reduces changes in the cerebellar Purkinje cells population in PDC‑deficient mice.
Topics: Animals; Brain; Cerebellar Cortex; Cerebellum; Disease Models, Animal; Mice, Transgenic; Neurons; Ph | 2020 |
Role of endoplasmic reticulum stress in renal damage after myocardial infarction.
Topics: Adult; Animals; Cells, Cultured; Disease Models, Animal; Endoplasmic Reticulum Stress; Female; Fibro | 2021 |
Chemical chaperones targeted to the endoplasmic reticulum (ER) and lysosome prevented neurodegeneration in a C9orf72 repeat expansion drosophila amyotrophic lateral sclerosis (ALS) model.
Topics: Amyotrophic Lateral Sclerosis; Animals; C9orf72 Protein; Disease Models, Animal; DNA Repeat Expansio | 2021 |
Sodium phenylbutyrate reduces repetitive self-grooming behavior and rescues social and cognitive deficits in mouse models of autism.
Topics: Animals; Antineoplastic Agents; Autism Spectrum Disorder; Brain; Cognitive Dysfunction; Disease Mode | 2021 |
4-Phenylbutyrate (PBA) treatment reduces hyperglycemia and islet amyloid in a mouse model of type 2 diabetes and obesity.
Topics: Amyloid; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal | 2021 |
Cardiac abnormalities after induction of endoplasmic reticulum stress are associated with mitochondrial dysfunction and connexin43 expression.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Apoptosis; Connexin 43; Disease Models, Animal; En | 2021 |
Endoplasmic Reticulum Stress Is Associated With Autophagy and Cardiomyocyte Remodeling in Experimental and Human Atrial Fibrillation.
Topics: Animals; Atrial Fibrillation; Atrial Remodeling; Autophagy; Calcium Channels, L-Type; Calcium Signal | 2017 |
Endoplasmic reticulum stress-dependent ROS production mediates synovial myofibroblastic differentiation in the immobilization-induced rat knee joint contracture model.
Topics: Adult; Animals; Antioxidants; Cell Differentiation; Contracture; Disease Models, Animal; Endoplasmic | 2018 |
Amelioration of hyperoxaluria-induced kidney dysfunction by chemical chaperone 4-phenylbutyric acid.
Topics: Animals; Biomarkers; Calcium Oxalate; Disease Models, Animal; Drug Evaluation, Preclinical; Endoplas | 2019 |
4-Phenylbutyric Acid Attenuates Endoplasmic Reticulum Stress-Mediated Intestinal Epithelial Cell Apoptosis in Rats with Severe Acute Pancreatitis.
Topics: Acute Disease; Animals; Apoptosis; Apoptosis Regulatory Proteins; Disease Models, Animal; Endoplasmi | 2019 |
Sodium 4-phenylbutyrate treatment protects against renal injury in NZBWF1 mice.
Topics: Albuminuria; Animals; Apoptosis; Crosses, Genetic; Disease Models, Animal; Endoplasmic Reticulum Cha | 2019 |
Endoplasmic reticulum stress inhibition blunts the development of essential hypertension in the spontaneously hypertensive rat.
Topics: Animals; Antihypertensive Agents; Biomarkers; Blood Pressure; Disease Models, Animal; Endoplasmic Re | 2019 |
Increased ER Stress After Experimental Ischemic Optic Neuropathy and Improved RGC and Oligodendrocyte Survival After Treatment With Chemical Chaperon.
Topics: Animals; Disease Models, Animal; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; | 2019 |
Treatment of keratinocytes with 4-phenylbutyrate in epidermolysis bullosa: Lessons for therapies in keratin disorders.
Topics: Animals; Apoptosis; Biomarkers; Biopsy; Cell Adhesion; Cell Communication; Cell Line; Cytoskeleton; | 2019 |
Shifting the balance of autophagy and proteasome activation reduces proteotoxic cell death: a novel therapeutic approach for restoring photoreceptor homeostasis.
Topics: Animals; Autophagy; Cell Death; Disease Models, Animal; Endoplasmic Reticulum; Endoplasmic Reticulum | 2019 |
Chemical chaperones improve the functional recovery of stunned myocardium by attenuating the endoplasmic reticulum stress.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cholagogues and Choleretics; Disease Models, Animal; Endo | 2020 |
Phenylbutyrate is a multifaceted drug that exerts neuroprotective effects and reverses the Alzheimer´s disease-like phenotype of a commonly used mouse model.
Topics: Acetylation; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Biomarkers; Butyric Acid; C | 2013 |
Phenylbutyrate is a multifaceted drug that exerts neuroprotective effects and reverses the Alzheimer´s disease-like phenotype of a commonly used mouse model.
Topics: Acetylation; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Biomarkers; Butyric Acid; C | 2013 |
Phenylbutyrate is a multifaceted drug that exerts neuroprotective effects and reverses the Alzheimer´s disease-like phenotype of a commonly used mouse model.
Topics: Acetylation; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Biomarkers; Butyric Acid; C | 2013 |
Phenylbutyrate is a multifaceted drug that exerts neuroprotective effects and reverses the Alzheimer´s disease-like phenotype of a commonly used mouse model.
Topics: Acetylation; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Biomarkers; Butyric Acid; C | 2013 |
The zebrafish as a model to study polycystic liver disease.
Topics: Animals; Antineoplastic Agents; Calcium-Binding Proteins; Cysts; Disease Models, Animal; DNA Helicas | 2013 |
Suppression of endoplasmic reticulum stress improves endothelium-dependent contractile responses in aorta of the spontaneously hypertensive rat.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Aorta; Arachidonic Acid; bcl-2-Associated X Protein | 2013 |
Endoplasmic reticulum stress participates in aortic valve calcification in hypercholesterolemic animals.
Topics: Aged; Animals; Aortic Valve; Aortic Valve Stenosis; Apolipoproteins E; Calcinosis; Calcium; Cell Dif | 2013 |
The effect of inhibition of endoplasmic reticulum stress on lipolysis in white adipose tissue in a rat model of chronic kidney disease.
Topics: Acyltransferases; Adipocytes; Animals; Cells, Cultured; Disease Models, Animal; eIF-2 Kinase; Endopl | 2014 |
No amelioration of uromodulin maturation and trafficking defect by sodium 4-phenylbutyrate in vivo: studies in mouse models of uromodulin-associated kidney disease.
Topics: Animals; Cytoplasm; Disease Models, Animal; Gout; Homozygote; HSP70 Heat-Shock Proteins; Hyperuricem | 2014 |
Ocular-specific ER stress reduction rescues glaucoma in murine glucocorticoid-induced glaucoma.
Topics: Animals; Antineoplastic Agents; Dexamethasone; Disease Models, Animal; Endoplasmic Reticulum Stress; | 2014 |
Phenylbutyric acid protects against spatial memory deficits in a model of repeated electroconvulsive therapy.
Topics: Animals; Blotting, Western; Brain; Disease Models, Animal; Electroconvulsive Therapy; Long-Term Pote | 2014 |
Endoplasmic reticulum stress response and bone loss in experimental periodontitis in mice.
Topics: Alveolar Bone Loss; Animals; Bone Marrow Cells; Cathepsin K; Cell Differentiation; Cells, Cultured; | 2015 |
Chemical corrector treatment ameliorates increased seizure susceptibility in a mouse model of familial epilepsy.
Topics: ADAM Proteins; Animals; Disease Models, Animal; Epilepsy, Frontal Lobe; Genetic Predisposition to Di | 2015 |
Pharmacological Interventions to Ameliorate Neuropathological Symptoms in a Mouse Model of Lafora Disease.
Topics: Animals; Brain; Disease Models, Animal; Fluorescent Antibody Technique; Gliosis; Glucans; Hippocampu | 2016 |
Role of epidermal growth factor receptor and endoplasmic reticulum stress in vascular remodeling induced by angiotensin II.
Topics: ADAM Proteins; ADAM17 Protein; Angiotensin II; Animals; Disease Models, Animal; Endoplasmic Reticulu | 2015 |
4-PBA prevents pressure overload-induced myocardial hypertrophy and interstitial fibrosis by attenuating endoplasmic reticulum stress.
Topics: Acetylation; Animals; Cardiomegaly; Disease Models, Animal; Dose-Response Relationship, Drug; Endopl | 2015 |
Involvement of endoplasmic reticulum stress in the necroptosis of microglia/macrophages after spinal cord injury.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Endoplasmic Reticulum Chaperone BiP; Endoplasmic R | 2015 |
4-Phenylbutyrate Benefits Traumatic Hemorrhagic Shock in Rats by Attenuating Oxidative Stress, Not by Attenuating Endoplasmic Reticulum Stress.
Topics: Animals; Disease Models, Animal; Endoplasmic Reticulum Stress; Female; Kaplan-Meier Estimate; Male; | 2016 |
The Dichotomy of Endoplasmic Reticulum Stress Response in Liver Ischemia-Reperfusion Injury.
Topics: Activating Transcription Factors; Adenine; AMP-Activated Protein Kinases; Animals; Autophagy; Autoph | 2016 |
4-Phenylbutyric acid regulates CCl4-induced acute hepatic dyslipidemia in a mouse model: A mechanism-based PK/PD study.
Topics: Animals; Apolipoproteins B; Carbon Tetrachloride; Cytochrome P-450 CYP2E1; Disease Models, Animal; D | 2016 |
4-Phenylbutyric Acid Reveals Good Beneficial Effects on Vital Organ Function via Anti-Endoplasmic Reticulum Stress in Septic Rats.
Topics: Animals; Apoptosis; Caspases; Cytokines; Disease Models, Animal; Endoplasmic Reticulum Stress; Femal | 2016 |
Amelioration of ER stress by 4-phenylbutyric acid reduces chronic hypoxia induced cardiac damage and improves hypoxic tolerance through upregulation of HIF-1α.
Topics: Altitude; Animals; Apoptosis; Apoptosis Regulatory Proteins; Chronic Disease; Cytoprotection; Diseas | 2016 |
Neuroprotection by Epigenetic Modulation in a Transgenic Model of Multiple System Atrophy.
Topics: Aging; alpha-Synuclein; Animals; Brain; Disease Models, Animal; Epigenesis, Genetic; Female; Gait Di | 2016 |
Tauopathy induced by low level expression of a human brain-derived tau fragment in mice is rescued by phenylbutyrate.
Topics: Animals; Behavior, Animal; Cognitive Dysfunction; Disease Models, Animal; Female; Humans; Male; Mice | 2016 |
4-Phenylbutyric Acid Induces Protection against Pulmonary Arterial Hypertension in Rats.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Disease Models, Animal; eIF-2 Kinase; Endoplasmic | 2016 |
Beneficial Effects of Sodium Phenylbutyrate Administration during Infection with Salmonella enterica Serovar Typhimurium.
Topics: Animals; Disease Models, Animal; Immunity, Mucosal; Inflammation; Interleukin-17; Interleukin-23; In | 2016 |
Molecular Mechanism Underlying Pathogenesis of Lewisite-Induced Cutaneous Blistering and Inflammation: Chemical Chaperones as Potential Novel Antidotes.
Topics: Acetylcysteine; Animals; Antidotes; Antioxidants; Arsenicals; Blister; Chemical Warfare Agents; Dise | 2016 |
Endoplasmic Reticulum Stress May Play a Pivotal Role in Lipid Metabolic Disorders in a Novel Mouse Model of Subclinical Hypothyroidism.
Topics: Animals; Disease Models, Animal; Endoplasmic Reticulum Stress; Humans; Hypothyroidism; Lipid Metabol | 2016 |
In silico Screening and Evaluation of the Anticonvulsant Activity of Docosahexaenoic Acid-Like Molecules in Experimental Models of Seizures.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Docosahexaenoic Acids; Drug Design; Electroshock; | 2017 |
Sodium 4-Phenylbutyrate Attenuates Myocardial Reperfusion Injury by Reducing the Unfolded Protein Response.
Topics: Animals; Apoptosis; Disease Models, Animal; Gene Expression Regulation; Male; Mice, Inbred C57BL; My | 2017 |
Endoplasmic reticulum stress inhibition limits the progression of chronic kidney disease in the Dahl salt-sensitive rat.
Topics: Animals; Blood Pressure; Disease Models, Animal; Disease Progression; Endoplasmic Reticulum Stress; | 2017 |
Endoplasmic reticulum stress inhibition attenuates hypertensive chronic kidney disease through reduction in proteinuria.
Topics: Angiotensin II; Animals; Apoptosis; Biopsy; Blood Pressure; Disease Models, Animal; Endoplasmic Reti | 2017 |
Novel Treatment of Chronic Graft-Versus-Host Disease in Mice Using the ER Stress Reducer 4-Phenylbutyric Acid.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Chronic Disease; Disease Models, Animal; Endoplasmi | 2017 |
4-Phenylbutyric acid and metformin decrease sensitivity to pentylenetetrazol-induced seizures in a malin knockout model of Lafora disease.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Disease Models, Animal; Dose-Response Relationship, Dr | 2017 |
4-PBA inhibits LPS-induced inflammation through regulating ER stress and autophagy in acute lung injury models.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Autophagy; Cell Line, Tumor; Cytokines; Cytopr | 2017 |
Phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an Alzheimer's disease mouse model.
Topics: Acetylation; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of V | 2009 |
Phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an Alzheimer's disease mouse model.
Topics: Acetylation; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of V | 2009 |
Phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an Alzheimer's disease mouse model.
Topics: Acetylation; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of V | 2009 |
Phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an Alzheimer's disease mouse model.
Topics: Acetylation; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of V | 2009 |
4-Phenyl butyric acid does not generally reduce glucose levels in rodent models of diabetes.
Topics: Animals; Blood Glucose; Blood Proteins; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; | 2010 |
Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Animals; CA1 Region, Hippocampal; Dendritic S | 2012 |
Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Animals; CA1 Region, Hippocampal; Dendritic S | 2012 |
Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Animals; CA1 Region, Hippocampal; Dendritic S | 2012 |
Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Animals; CA1 Region, Hippocampal; Dendritic S | 2012 |
Topical ocular sodium 4-phenylbutyrate rescues glaucoma in a myocilin mouse model of primary open-angle glaucoma.
Topics: Administration, Ophthalmic; Animals; Anti-Bacterial Agents; Aqueous Humor; Cytoskeletal Proteins; Di | 2012 |
The chemical chaperone 4-phenylbutyric acid attenuates pressure-overload cardiac hypertrophy by alleviating endoplasmic reticulum stress.
Topics: Administration, Oral; Animals; Aorta; Apoptosis; Atrial Natriuretic Factor; Biomarkers; Cardiomegaly | 2012 |
Attenuating endoplasmic reticulum stress as a novel therapeutic strategy in pulmonary hypertension.
Topics: Activating Transcription Factor 6; Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Ch | 2013 |
Aberrant endoplasmic reticulum stress in vascular smooth muscle increases vascular contractility and blood pressure in mice deficient of AMP-activated protein kinase-α2 in vivo.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Angiotensin II; Animals; Antihypertensive | 2013 |
Sodium 4-phenylbutyrate protects against cerebral ischemic injury.
Topics: Animals; Apoptosis; Brain Ischemia; Disease Models, Animal; Endoplasmic Reticulum; Male; Mice; Mice, | 2004 |
[Combination of phenylbutyrate and 5-Aza-2'deoxycytidine inhibits human Kasumi-1 xenograft tumor growth in nude mice].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Prolifera | 2004 |
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes.
Topics: Adipose Tissue; Animals; Blood Glucose; Cell Line, Tumor; Diabetes Mellitus, Type 2; Disease Models, | 2006 |
Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone.
Topics: alpha-Synuclein; Animals; Cells, Cultured; Corpus Striatum; Disease Models, Animal; Dopamine; Endopl | 2007 |
Cellular osmolytes reduce lens epithelial cell death and alleviate cataract formation in galactosemic rats.
Topics: Animals; Body Weight; Cataract; Cell Death; Cell Survival; Cells, Cultured; Disease Models, Animal; | 2007 |