4-phenylbutyric acid has been researched along with Diabetic Retinopathy in 2 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Diabetic Retinopathy: Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diabetic retinopathy is a chronic low-grade inflammatory disease; however, the mechanisms remain elusive." | 1.35 | Endoplasmic reticulum stress is implicated in retinal inflammation and diabetic retinopathy. ( Li, J; Wang, JJ; Wang, M; Yu, Q; Zhang, SX, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abdel-Ghaffar, A | 1 |
| Elhossary, GG | 1 |
| Mahmoud, AM | 1 |
| Elshazly, AHM | 1 |
| Hassanin, OA | 1 |
| Saleh, A | 1 |
| Mansour, SM | 1 |
| Metwally, FG | 1 |
| Hanafy, LK | 1 |
| Karam, SH | 1 |
| Darweesh, N | 1 |
| Ata, AM | 1 |
| Li, J | 1 |
| Wang, JJ | 1 |
| Yu, Q | 1 |
| Wang, M | 1 |
| Zhang, SX | 1 |
2 other studies available for 4-phenylbutyric acid and Diabetic Retinopathy
| Article | Year |
|---|---|
Effects of 4-phenylbutyric acid on the development of diabetic retinopathy in diabetic rats: regulation of endoplasmic reticulum stress-oxidative activation.
Topics: Animals; Apoptosis; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Endoplasmic Reticulum Str | 2023 |
Endoplasmic reticulum stress is implicated in retinal inflammation and diabetic retinopathy.
Topics: Animals; Base Sequence; Cells, Cultured; Diabetic Retinopathy; DNA Primers; Endoplasmic Reticulum; E | 2009 |