4-phenylbutyric acid has been researched along with Diabetic Nephropathies in 3 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Diabetic Nephropathies: KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The dosage of 4-PBA treatment was gavaged at a dose of 1 g/kg body weight each day for 12 weeks." | 1.37 | Attenuation of diabetic nephropathy in diabetes rats induced by streptozotocin by regulating the endoplasmic reticulum stress inflammatory response. ( Feng, B; Guo, YH; Liu, L; Luo, ZF; Mu, J; Pang, Q; Qi, W; Ye, ZL; Yuan, FH; Zeng, W, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cao, AL | 1 |
| Wang, L | 1 |
| Chen, X | 1 |
| Wang, YM | 1 |
| Guo, HJ | 1 |
| Chu, S | 1 |
| Liu, C | 1 |
| Zhang, XM | 1 |
| Peng, W | 1 |
| Luo, ZF | 2 |
| Feng, B | 2 |
| Mu, J | 2 |
| Qi, W | 2 |
| Zeng, W | 2 |
| Guo, YH | 2 |
| Pang, Q | 2 |
| Ye, ZL | 2 |
| Liu, L | 2 |
| Yuan, FH | 2 |
3 other studies available for 4-phenylbutyric acid and Diabetic Nephropathies
| Article | Year |
|---|---|
Ursodeoxycholic acid and 4-phenylbutyrate prevent endoplasmic reticulum stress-induced podocyte apoptosis in diabetic nephropathy.
Topics: Albuminuria; Animals; Apoptosis; Autophagy; Cells, Cultured; Diabetic Nephropathies; Endoplasmic Ret | 2016 |
Effects of 4-phenylbutyric acid on the process and development of diabetic nephropathy induced in rats by streptozotocin: regulation of endoplasmic reticulum stress-oxidative activation.
Topics: Animals; Antioxidants; Blood Urea Nitrogen; Creatinine; Diabetes Mellitus, Experimental; Diabetic Ne | 2010 |
Attenuation of diabetic nephropathy in diabetes rats induced by streptozotocin by regulating the endoplasmic reticulum stress inflammatory response.
Topics: Animals; Chemokine CCL2; Cytokines; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Endopla | 2011 |